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MAFA 抗体 (Cy7)

This anti-MAFA antibody is a 兔 多克隆 antibody detecting MAFA in WB 和 IF (p). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN729904
发货至: 中国

Quick Overview for MAFA 抗体 (Cy7) (ABIN729904)

抗原

See all MAFA 抗体
MAFA (Transcription Factor MafA (MAFA))

适用

  • 48
  • 35
  • 21
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 49
  • 3

克隆类型

  • 49
  • 3
多克隆

标记

  • 30
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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This MAFA antibody is conjugated to Cy7

应用范围

  • 44
  • 16
  • 11
  • 4
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human Mafa

    亚型

    IgG
  • 应用备注

    IF(IHC-P): (1:50-200)
    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    MAFA (Transcription Factor MafA (MAFA))

    别名

    Mafa

    背景

    Synonyms: Mafa homolog, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A,Pancreatic beta-cell-specic transcriptional activator,avianV-maf musculoaponeurotic fibrosarcoma oncogene homolog A, MAFA_MOUSE.

    Background: Insulin gene expression is regulated by several islet-enriched transcription factors. However, MAFA is the only beta cell-specific activator. MAFA selectively induces endogenous insulin transcription in non-beta cells. MAFA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MAFA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.

    基因ID

    389692

    途径

    Hormone Transport
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