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Glypican 3 抗体 (Biotin)

This Human Chimeric antibody specifically detects Glypican 3 in IHC. It exhibits reactivity toward 人.
产品编号 ABIN7608235
发货至: 中国
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中国
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Quick Overview for Glypican 3 抗体 (Biotin) (ABIN7608235)

抗原

See all Glypican 3 (GPC3) 抗体
Glypican 3 (GPC3)

适用

  • 200
  • 62
  • 52
  • 4
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宿主

  • 115
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Human, 兔

克隆类型

  • 114
  • 84
  • 4
Chimeric

标记

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This Glypican 3 antibody is conjugated to Biotin

应用范围

  • 108
  • 87
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  • 59
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  • 26
  • 19
  • 17
  • 13
  • 6
  • 5
  • 2
  • 1
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Immunohistochemistry (IHC)

克隆位点

163D11
  • 原理

    Biotinylated Anti-GPC3 antibody(163D11), IgG1 Chimeric mAb

    纯化方法

    Purified from cell culture supernatant by affinity chromatography

    亚型

    IgG1
  • 应用备注

    IHC 1:100

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

    储存条件

    -20 °C,-80 °C

    储存方法

    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

    有效期

    12 months
  • 抗原

    Glypican 3 (GPC3)

    别名

    GPC3

    背景

    Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] References: Fu Ying,Urban Daniel J,Nani Roger R et al. Glypican-3-Specific Antibody Drug Conjugates Targeting Hepatocellular Carcinoma.[J] .Hepatology, 2019, 70: 563-576. Zhang Yi-Fan,Ho Mitchell,Humanization of high-affinity antibodies targeting glypican-3 in hepatocellular carcinoma.[J] .Sci Rep, 2016, 6: 33878.

    UniProt

    P51654

    途径

    Glycosaminoglycan Metabolic Process
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