CXCR2 抗体 (Biotin)
Quick Overview for CXCR2 抗体 (Biotin) (ABIN7608177)
抗原
See all CXCR2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Biotinylated Anti-CXCR2 antibody(DMC681), IgG1 Chimeric mAb
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纯化方法
- Purified from cell culture supernatant by affinity chromatography
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亚型
- IgG1
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应用备注
- Flow Cyt 1:100
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))
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别名
- CXCR2
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背景
- The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1:MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
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UniProt
- P25025, Q53PC4
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途径
- cAMP Metabolic Process
抗原
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