CD5L 抗体 (Biotin)
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北京 101111
Quick Overview for CD5L 抗体 (Biotin) (ABIN7608123)
抗原
See all CD5L 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Biotinylated Anti-CD5L antibody(DMC441), IgG1 Chimeric mAb
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纯化方法
- Purified from cell culture supernatant by affinity chromatography
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亚型
- IgG1
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anti-CD5 Molecule-Like (CD5L) (AA 41-140) antibody
CD5L 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-CD5 Molecule-Like (CD5L) (AA 1-347) antibodyCD5L 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) (AA 221-347) antibodyCD5L 适用: 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) antibodyCD5L 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) (AA 64-93), (N-Term) antibodyCD5L 适用: 人 WB 宿主: 兔 Polyclonal RB41686 unconjugated
anti-CD5 Molecule-Like (CD5L) (C-Term) antibodyCD5L 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) (N-Term) antibodyCD5L 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) (AA 20-347) antibodyCD5L 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) (AA 133-256) antibodyCD5L 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-CD5 Molecule-Like (CD5L) antibodyCD5L 适用: 人 FACS 宿主: 兔 Chimeric unconjugated Fc fragment
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应用备注
- Flow Cyt 1:100
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- CD5L (CD5 Molecule-Like (CD5L))
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别名
- CD5L
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背景
- Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha:mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).
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UniProt
- O43866
抗原
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