MTMR2 抗体 (N-Term)
Quick Overview for MTMR2 抗体 (N-Term) (ABIN7603228)
抗原
See all MTMR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Anti-MTMR2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-MTMR2 Antibody Picoband® (ABIN7603228). Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human MTMR2, identical to the related mouse sequences.
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亚型
- IgG
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anti-Myotubularin Related Protein 2 (MTMR2) (AA 5-100) antibody
MTMR2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G6 unconjugated
anti-Myotubularin Related Protein 2 (MTMR2) (AA 1-173) antibodyMTMR2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myotubularin Related Protein 2 (MTMR2) (AA 404-643) antibodyMTMR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Myotubularin Related Protein 2 (MTMR2) (C-Term) antibodyKO Validated MTMR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Begley, M. J., Taylor, G. S., Brock, M. A., Ghosh, P., Woods, V. L., Dixon, J. E. Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc. Nat. Acad. Sci. 103: 927-932, 2006. 2. Berger, P., Bonneick, S., Willi, S., Wymann, M., Suter, U. Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1. Hum. Molec. Genet. 11: 1569-1579, 2002. 3. Berger, P., Schaffitzel, C., Berger, I., Ban, N., Suter, U. Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module. Proc. Nat. Acad. Sci. 100: 12177-12182, 2003. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- MTMR2 (Myotubularin Related Protein 2 (MTMR2))
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别名
- MTMR2
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背景
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Synonyms: Transforming acidic coiled-coil-containing protein 1,Gastric cancer antigen Ga55,Taxin-1,TACC1,KIAA1103,
Tissue Specificity: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. .
Background: Myotubularin-related protein 2 also known as phosphatidylinositol-3,5-bisphosphate 3-phosphatase or phosphatidylinositol-3-phosphate phosphatase is a protein that in humans is encoded by the MTMR2 gene. This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene.
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分子量
- 73 kDa
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基因ID
- 8898
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UniProt
- Q13614
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途径
- Inositol Metabolic Process, Synaptic Membrane
抗原
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