GADD45B 抗体 (N-Term)
Quick Overview for GADD45B 抗体 (N-Term) (ABIN7603219)
抗原
See all GADD45B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Anti-GADD45B Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-GADD45B Antibody Picoband® (ABIN7603219). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human GADD45B, which shares 94.7% amino acid (aa) sequence identity with mouse GADD45B.
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亚型
- IgG
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anti-Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) (Middle Region) antibody
GADD45B 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Pig IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) (AA 81-160) antibodyGADD45B 适用: 人, 小鼠 ELISA, WB, FACS, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) (AA 1-160) antibodyGADD45B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) (AA 1-160) antibodyGADD45B 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) (C-Term) antibodyGADD45B 适用: 人, 小鼠, 大鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Arrest and DNA-Damage-Inducible, beta (GADD45B) (Middle Region) antibodyGADD45B 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
1. De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D. U., Jin, R., Jones, J., Cong, R., Franzoso, G. Induction of gadd45-beta by NF-kappa-B downregulates pro-apoptotic JNK signaling. Nature 414: 308-313, 2001. 2. Ma, D. K., Jang, M.-H., Guo, J. U., Kitabatake, Y., Chang, M., Pow-anpongkul, N., Flavell, R. A., Lu, B., Ming, G., Song, H. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 323: 1074-1077, 2009. 3. Takekawa, M., Saito, H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95: 521-530, 1998. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- GADD45B (Growth Arrest and DNA-Damage-Inducible, beta (GADD45B))
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别名
- GADD45B
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背景
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Synonyms: Rhombotin-2, Cysteine-rich protein TTG-2, LIM domain only protein 2, LMO-2, T-cell translocation protein 2, LMO2, RBTN2, RBTNL1, RHOM2, TTG2
Background: Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a protein which in humans is encoded by the GADD45B gene. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.
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分子量
- 18 kDa
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基因ID
- 4616
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UniProt
- O75293
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途径
- Cell Division Cycle
抗原
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