KPNA1 抗体 (N-Term)
Quick Overview for KPNA1 抗体 (N-Term) (ABIN7603189)
抗原
See all KPNA1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Anti-SRP1/KPNA1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-SRP1/KPNA1 Antibody Picoband® (ABIN7603189). Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human SRP1/KPNA1, which shares 89.3% and 92.9% amino acid (aa) sequence identity with mouse and rat SRP1/KPNA1, respectively.
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亚型
- IgG
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anti-Karyopherin alpha 1 (Importin alpha 5) (KPNA1) (AA 1-300) antibody
KPNA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 1 (Importin alpha 5) (KPNA1) (AA 1-538) antibodyKPNA1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2A4-1B5 unconjugated
anti-Karyopherin alpha 1 (Importin alpha 5) (KPNA1) (AA 1-538) antibodyKPNA1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Karyopherin alpha 1 (Importin alpha 5) (KPNA1) (AA 1-538) antibodyKPNA1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Karyopherin alpha 1 (Importin alpha 5) (KPNA1) (AA 1-538) antibodyKPNA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 1 (Importin alpha 5) (KPNA1) (AA 239-506) antibodyKPNA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 1 (Importin alpha 5) (KPNA1) (AA 8-538) antibodyKPNA1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 1 (Importin alpha 5) (KPNA1) (AA 1-539) antibodyKPNA1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2A4-1B5 unconjugated
anti-Karyopherin alpha 1 (Importin alpha 5) (KPNA1) (N-Term) antibodyKPNA1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 1 (Importin alpha 5) (KPNA1) (N-Term) antibodyVerified KPNA1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Ayala-Madrigal, M. L., Doerr, S., Ramirez-Duenas, M. L., Hansmann, I. Assignment of karyopherin alpha 1 (KPNA1) to human chromosome band 3q21 by in situ hybridization. Cytogenet. Cell Genet. 90: 58-59, 2000. 2. Conti, E., Uy, M., Leighton, L., Blobel, G., Kuriyan, J. Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell 94: 193-204, 1998. 3. Cortes, P., Ye, Z.-S., Baltimore, D. RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc. Nat. Acad. Sci. 91: 7633-7637, 1994. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))
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别名
- KPNA1
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背景
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Synonyms: Homeobox protein Hox-A5, Homeobox protein Hox-1C, HOXA5, HOX1C
Tissue Specificity: Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Background: Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene. The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants.
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分子量
- 60 kDa
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基因ID
- 3836
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UniProt
- P52294
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途径
- M Phase, Protein targeting to Nucleus
抗原
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