IL2RG 抗体 (N-Term)
Quick Overview for IL2RG 抗体 (N-Term) (ABIN7603175)
抗原
See all IL2RG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Anti-IL2 Receptor gamma/IL2RG Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-IL2 Receptor gamma/IL2RG Antibody Picoband® (ABIN7603175). Tested in IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human IL2 Receptor gamma/IL2RG, which shares 78.9% amino acid (aa) sequence identity with both mouse and rat IL2 Receptor gamma/IL2RG.
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亚型
- IgG
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anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 51-150) antibody
IL2RG 适用: 人, 大鼠 WB, FACS, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-262) antibodyIL2RG 适用: 人 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 4A8E5 unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-262) antibodyIL2RG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A8F2 unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 76-101), (N-Term) antibodyIL2RG 适用: 人 WB, FACS, IF 宿主: 兔 Polyclonal RB22117 unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-262) antibodyIL2RG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 23-263) antibodyIL2RG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) antibody (APC)IL2RG 适用: 人, 犬 FACS 宿主: 大鼠 Monoclonal TUGh4 APC
anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 75-230) antibodyIL2RG 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) antibodyIL2RG 适用: 人, 犬 FACS 宿主: 大鼠 Monoclonal TUGh4 unconjugated
anti-Interleukin 2 Receptor, gamma (IL2RG) (N-Term) antibodyIL2RG 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
1. Asao, H., Okuyama, C., Kumaki, S., Ishii, N., Tsuchiya, S., Foster, D., Sugamura, K. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J. Immun. 167: 1-5, 2001. 2. Brandt, K., Singh, P. B., Bulfone-Paus, S., Ruckert, R. Interleukin-21: a new modulator of immunity, infection, and cancer. Cytokine Growth Factor Rev. 18: 223-232, 2007. 3. PDB 2B5IWang X, Rickert M, Garcia KC (November 2005). "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors". Science 310 (5751): 1159-63. doi:10.1126/science.1117893. PMID 16293754. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- IL2RG (Interleukin 2 Receptor, gamma (IL2RG))
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别名
- IL2RG
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背景
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Synonyms: Interferon alpha/beta receptor 1,IFN-R-1,IFN-alpha/beta receptor 1,Cytokine receptor class-II member 1,Cytokine receptor family 2 member 1,CRF2-1,Type I interferon receptor 1,IFNAR1,IFNAR,
Tissue Specificity: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. .
Background: IL2RG (INTERLEUKIN 2 RECEPTOR, GAMMA),also known as Common gamma chain or CD132, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors:IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. IL2RG is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. By fluorescence in situ hybridization and PCR amplification of somatic cell hybrid DNAs, The IL2RG gene is mapped to Xq13.1. The IL2RG gene contains 8 exons and spans approximately 4.2 kb. And the gamma chain is an indispensable component of the functional IL2 receptor. Lymphocytes expressing the common gamma chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and programs of cellular differentiation. The sharing of the gamma subunit by several receptors explains why humans and mice that lack IL2 entirely show milder symptoms than those with IL2RG deficiency.
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分子量
- 65 kDa
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基因ID
- 3561
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UniProt
- P31785
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途径
- JAK/STAT Signaling, Growth Factor Binding
抗原
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