Ghrelin 抗体 (Middle Region)
Quick Overview for Ghrelin 抗体 (Middle Region) (ABIN7603053)
抗原
See all Ghrelin (GHRL) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- Anti-Ghrelin/GHRL Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Ghrelin/GHRL Antibody Picoband® (ABIN7603053). Tested in IHC applications. This antibody reacts with Human.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human Ghrelin/GHRL, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Ghrelin (GHRL) (AA 1-117) antibody
GHRL 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F4 unconjugated
anti-Ghrelin (GHRL) (AA 28-117) antibodyGHRL 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ghrelin (GHRL) antibodyGHRL 适用: 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ghrelin (GHRL) (AA 1-117) antibodyGHRL 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ghrelin (GHRL) (AA 25-117) antibodyGHRL 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ghrelin (GHRL) (C-Term) antibodyVerified GHRL 适用: 人, 大鼠 ELISA, IHC, ICC 宿主: 山羊 Polyclonal unconjugated
anti-Ghrelin (GHRL) (AA 31-117) antibodyGHRL 适用: 人, 大鼠 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ghrelin (GHRL) (AA 1-117) antibodyGHRL 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ghrelin (GHRL) (C-Term) antibodyGHRL 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ghrelin (GHRL) (AA 1-118) antibodyGHRL 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2F4 unconjugated
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应用备注
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Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
1. Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschop, M. H., Gao, X.-B., Horvath, T. L. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J. Clin. Invest. 116: 3229-3239, 2006. 2. Andrews, Z. B., Liu, Z.-W., Wallingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschop, M. H., Shanabrough, M., Cline, G., Shulman, G. I., Coppola, A., Gao, X.-B., Horvath, T. L., Diano, S. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 454: 846-851, 2008. Note: Erratum: Nature 459: 736 only, 2009. 3. Chartrel, N., Alvear-Perez, R., Leprince, J., Iturrioz, X., Reaux-Le Goazigo, A., Audinot, V., Chomarat, P., Coge, F., Nosjean, O., Rodriguez, M., Galizzi, J. P., Boutin, J. A., Vaudry, H., Llorens-Cortes, C. Comment on 'Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.' Science 315: 766 only, 2007. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Ghrelin (GHRL)
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别名
- GHRL
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背景
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Synonyms: Fibroblast growth factor 10, FGF-10, Keratinocyte growth factor 2, FGF10
Tissue Specificity: Expressed in numerous tissues with highest level in testis.
Background: This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression.
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分子量
- 20 kDa
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基因ID
- 51738
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途径
- Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Negative Regulation of Hormone Secretion, Synaptic Membrane, Feeding Behaviour
抗原
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