GPX3 抗体 (C-Term)
Quick Overview for GPX3 抗体 (C-Term) (ABIN7602892)
抗原
See all GPX3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-GPX3 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-GPX3 Antibody Picoband® (ABIN7602892). Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human GPX3. Human GPX3 shares 100% amino acid (aa) sequence identity with both mouse and rat GPX3.
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亚型
- IgG
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anti-Glutathione Peroxidase 3 (Plasma) (GPX3) (AA 21-72) antibody
GPX3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Peroxidase 3 (Plasma) (GPX3) (AA 3-72) antibodyGPX3 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Peroxidase 3 (Plasma) (GPX3) (Internal Region) antibodyVerified GPX3 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Glutathione Peroxidase 3 (Plasma) (GPX3) (AA 93-123) antibodyGPX3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB18898 unconjugated
anti-Glutathione Peroxidase 3 (Plasma) (GPX3) (N-Term) antibodyGPX3 适用: 人, 小鼠, 大鼠, 犬, Pig, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutathione Peroxidase 3 (Plasma) (GPX3) antibodyGPX3 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse, Rat
1. Chambers, I., Frampton, J., Goldfarb, P., Affara, N., McBain, W., Harrison, P. R. The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA. EMBO J. 5: 1221-1227, 1986. 2. Chu, F.-F. The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively. Cytogenet. Cell Genet. 66: 96-98, 1994. 3. Chu, F.-F., Esworthy, R. S., Doroshow, J. H., Doan, K., Liu, X.-F. Expression of glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents. Blood 79: 3233-3238, 1992. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- GPX3 (Glutathione Peroxidase 3 (Plasma) (GPX3))
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别名
- GPX3
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背景
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Synonyms: GPX3, GPXP, Glutathione peroxidase 3, GPx-3, GSHPx-3, EC 1.11.1.9, Extracellular glutathione peroxidase, Plasma glutathione peroxidase, GPx-P, GSHPx-P
Background: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
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分子量
- 26 kDa
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基因ID
- 2878
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UniProt
- P22352
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途径
- Thyroid Hormone Synthesis
抗原
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