FOXL2 抗体 (C-Term)
Quick Overview for FOXL2 抗体 (C-Term) (ABIN7602885)
抗原
See all FOXL2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-FOXL2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-FOXL2 Antibody Picoband® (ABIN7602885). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human FOXL2, identical to the related mouse sequences.
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亚型
- IgG
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anti-Forkhead Box L2 (FOXL2) (C-Term) antibody
Verified FOXL2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box L2 (FOXL2) (C-Term) antibodyFOXL2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box L2 (FOXL2) (C-Term) antibodyFOXL2 适用: 人, 小鼠, 大鼠, Cow, Pig, 兔, 山羊, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box L2 (FOXL2) antibodyFOXL2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Forkhead Box L2 (FOXL2) (AA 3-29), (N-Term) antibodyFOXL2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB22898 unconjugated
anti-Forkhead Box L2 (FOXL2) (AA 116-216) antibodyFOXL2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box L2 (FOXL2) antibodyFOXL2 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box L2 (FOXL2) antibodyFOXL2 适用: 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box L2 (FOXL2) (N-Term) antibodyFOXL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Aparicio, S., Chapman, J., Stupka, E., Putnam, N., Chia, J., Dehal, P., Christoffels, A., Rash, S., Hoon, S., Smit, A., Gelpke, M. D. S., Roach, J., and 29 others. Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science 297: 1301-1310, 2002. 2. Benayoun, B. A., Batista, F., Auer, J., Dipietromaria, A., L'Hote, D., De Baere, E., Veitia, R. A. Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations. Hum. Molec. Genet. 18: 632-644, 2009. 3. Benayoun, B. A., Caburet, S., Dipietromaria, A., Bailly-Bechet, M., Batista, F., Fellous, M., Vaiman, D., Veitia, R. A. The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles. Hum. Molec. Genet. 17: 3118-3127, 2008. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- FOXL2 (Forkhead Box L2 (FOXL2))
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别名
- FOXL2
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背景
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Synonyms: DNA dC->dU-editing enzyme APOBEC-3A, A3A, Phorbolin-1, APOBEC3A
Tissue Specificity: Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia.
Background: The forkhead transcription factor gene, FOXL2 located in blepharophimosis-ptosis-epicanthus inversus syndrome(BPES) critical region on chromosome 3q23. Consistent with an involvement in BPES, FOXL2 is selectively expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles, in adult humans, it appears predominantly in the ovary. FOXL2 haploinsufficiency may cause BPES types I and II by the effect of a null allele and a hypomorphic allele, respectively. Furthermore, in a fraction of the BPES patients the genetic defect does not reside within the coding region of the FOXL2 gene and may be caused by a position effect. FOXL2 mutations can also cause gonadal dysgenesis or premature ovarian failure(POF) in women, as well as eyelid/forehead dysmorphology in both sexes.
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分子量
- 50 kDa
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基因ID
- 668
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UniProt
- P58012
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途径
- Nuclear Hormone Receptor Binding, Positive Regulation of Endopeptidase Activity
抗原
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