SYNPO 抗体 (C-Term)
Quick Overview for SYNPO 抗体 (C-Term) (ABIN7602840)
抗原
See all SYNPO 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-Synaptopodin/SYNPO Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Synaptopodin/SYNPO Antibody Picoband® (ABIN7602840). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Synaptopodin/SYNPO, which shares 100% and 94.3% amino acid (aa) sequence identity with mouse and rat Synaptopodin/SYNPO, respectively.
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亚型
- IgG
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anti-Synaptopodin (SYNPO) (AA 331-452), (Isoform 2) antibody
SYNPO 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synaptopodin (SYNPO) (AA 97-300) antibodySYNPO 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Synaptopodin (SYNPO) (AA 331-452), (Isoform 2) antibodySYNPO 适用: 小鼠, 大鼠 IHC, ICC 宿主: 豚鼠 Polyclonal unconjugated
anti-Synaptopodin (SYNPO) (AA 601-700) antibodySYNPO 适用: 小鼠, 大鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Synaptopodin (SYNPO) (AA 601-700) antibody (FITC)SYNPO 适用: 小鼠, 大鼠 WB, FACS 宿主: 兔 Polyclonal FITC
anti-Synaptopodin (SYNPO) (C-Term) antibodySYNPO 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Synaptopodin (SYNPO) (AA 1-260) antibodySYNPO 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Cooney, Hurlburt, JL, Selig, DK, Harris, KM, Fiala, JC (2002). "Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane". The Journal of neuroscience : the official journal of the Society for Neuroscience 22 (6): 2215-24. 2. Deller, Merten, T, Roth, SU, Mundel, P, Frotscher, M (2000). "Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons". The Journal of Comparative Neurology 418 (2): 164-81 3. Gray (1959). "Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex". Nature 183 (4675): 1592-3. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- SYNPO (Synaptopodin (SYNPO))
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别名
- SYNPO
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背景
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Synonyms: Glycogen synthase kinase-3 alpha, GSK-3 alpha, Serine/threonine-protein kinase GSK3A, GSK3A
Tissue Specificity: Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
Background: The spine apparatus (SA) is a specialized form of endoplasmic reticulum (ER) that is found in a subpopulation of dendritic spines in central neurons. The SA consists of a series of stacked discs that are though to be connected to each other and to the dendritic system of ER-tubules. The actin binding protein synaptopodin (which has originally been described in podocytes of the kidney) is an essential component of the SA. Mice that lack the gene for synaptopodin do not form a spine apparatus. The SA is believed to play a critical role in learning and memory. In summary, an important function of the spine apparatus is the regulation of plasticity at individual synapses, a process known as metaplasticity. The International Radiation Hybrid Mapping Consortium mapped the SYNPO gene to chromosome 5.
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分子量
- 99 kDa
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基因ID
- 11346
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UniProt
- Q8N3V7
抗原
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