POR 抗体 (C-Term)
Quick Overview for POR 抗体 (C-Term) (ABIN7602795)
抗原
See all POR 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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原理
- Anti-POR Antibody Picoband® (monoclonal, 7F5)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-POR Antibody Picoband® (monoclonal, 7F5) (ABIN7602795). Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human POR, different from the related mouse and rat sequences by five amino acids.
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亚型
- IgG2b
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anti-P450 (Cytochrome) Oxidoreductase (POR) (AA 77-518) antibody
POR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-P450 (Cytochrome) Oxidoreductase (POR) (AA 1-680) antibodyPOR 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-P450 (Cytochrome) Oxidoreductase (POR) (AA 1-250) antibodyPOR 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-P450 (Cytochrome) Oxidoreductase (POR) (N-Term) antibodyKO Validated POR 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-P450 (Cytochrome) Oxidoreductase (POR) antibodyPOR 适用: 人, 大鼠, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-P450 (Cytochrome) Oxidoreductase (POR) (C-Term) antibodyPOR 适用: 人, 大鼠, 小鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-P450 (Cytochrome) Oxidoreductase (POR) (AA 2-671) antibodyPOR 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P450 (Cytochrome) Oxidoreductase (POR) (AA 1-680) antibodyPOR 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-P450 (Cytochrome) Oxidoreductase (POR) (C-Term) antibodyKO Validated POR 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-P450 (Cytochrome) Oxidoreductase (POR) (AA 633-668), (C-Term) antibodyPOR 适用: 人, 大鼠, 小鼠 WB, IHC, FACS, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Adachi, M., Asakura, Y., Matsuo, M., Yamamoto, T., Hanaki, K., Arlt, W. POR R457H is a global founder mutation causing Antley-Bixler syndrome with autosomal recessive trait. (Letter) Am. J. Med. Genet. 140A: 633-635, 2006. 2. Miller, W. L. Congenital adrenal hyperplasia. (Letter) New Eng. J. Med. 314: 1321-1322, 1986. 3. Shephard, E. A., Phillips, I. R., Santisteban, I., West, L. F., Palmer, C. N., Ashworth, A., Povey, S. Isolation of a human cytochrome P-450 reductase cDNA clone and localization of the corresponding gene to chromosome 7q11.2. Ann. Hum. Genet. 53: 291-301, 1989. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- POR (P450 (Cytochrome) Oxidoreductase (POR))
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别名
- POR
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背景
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Synonyms: Keratin, type I cytoskeletal 19, Cytokeratin-19, CK-19, Keratin-19, K19, KRT19
Tissue Specificity: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
Background: POR is a membrane-boundenzyme required for electron transfer from NADPH to cytochrome P450 in the endoplasmic reticulum of theeukaryotic cell. The gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons ly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.
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分子量
- 77 kDa
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基因ID
- 5447
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UniProt
- P16435
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途径
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, SARS-CoV-2 Protein Interactome
抗原
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