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CD22 抗体 (C-Term)

This anti-CD22 antibody is a 小鼠 单克隆 antibody detecting CD22 in WB. Suitable for 人.
产品编号 ABIN7602740
发货至: 中国

Quick Overview for CD22 抗体 (C-Term) (ABIN7602740)

抗原

See all CD22 抗体
CD22 (CD22 Molecule (CD22))

适用

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  • 26
  • 5
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  • 1

宿主

  • 124
  • 81
  • 16
  • 3
小鼠

克隆类型

  • 161
  • 61
  • 1
单克隆

标记

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This CD22 antibody is un-conjugated

应用范围

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  • 19
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Western Blotting (WB)

克隆位点

5E7
  • 抗原表位

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    C-Term

    原理

    Anti-CD22 Antibody Picoband® (monoclonal, 5E7)

    交叉反应 (详细)

    No cross-reactivity with other proteins.

    产品特性

    Anti-CD22 Antibody Picoband® (monoclonal, 5E7) (ABIN7602740). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    免疫原

    A synthetic peptide corresponding to a sequence at the C-terminus of human CD22, different from the related mouse sequence by ten amino acids.

    亚型

    IgG2b
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human
    1. John, B., Herrin, B. R., Raman, C., Wang, Y., Bobbitt, K. R., Brody, B. A., Justement, L. B. The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction. J. Immun. 170: 3534-3543, 2003. 2. O'Keefe, T. L., Williams, G. T., Davies, S. L., Neuberger, M. S. Hyperresponsive B cells in CD22-deficient mice. Science 274: 798-801, 1996. 3. Wilson, G. L., Najfeld, V., Kozlow, E., Menniger, J., Ward, D., Kehrl, J. H. Genomic structure and chromosomal mapping of the human CD22 gene. J. Immun. 150: 5013-5024, 1993.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg NaN3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原

    CD22 (CD22 Molecule (CD22))

    别名

    CD22

    背景

    Synonyms: B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14, CD22, SIGLEC2

    Tissue Specificity: B-lymphocytes.

    Background: CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking. It is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering. The human CD22 gene is expressed specifically in B lymphocytes and likely has an important function in cell-cell interactions. The B cell coreceptor CD22 plays an important role in regulating signal transduction via the B cell Ag receptor. And CD22 is located within the band region q13.1 of chromosome 19.

    分子量

    140 kDa

    基因ID

    933

    UniProt

    P20273
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