RANBP2 抗体 (AA 906-2744)
Quick Overview for RANBP2 抗体 (AA 906-2744) (ABIN7602650)
抗原
See all RANBP2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 906-2744
-
原理
- Anti-RANBP2 Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-RANBP2 Antibody Picoband® (ABIN7602650). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human RANBP2 recombinant protein (Position: N906-D2744).
-
亚型
- IgG
-
-
anti-RAN Binding Protein 2 (RANBP2) antibody
RANBP2 适用: 人, 小鼠, 大鼠 ELISA, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RAN Binding Protein 2 (RANBP2) (AA 2601-2802) antibodyRANBP2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RAN Binding Protein 2 (RANBP2) (AA 1050-1100) antibodyRANBP2 适用: 人, 小鼠, 大鼠, Cow WB, IHC, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Beddow AL, Richards SA, Orem NR, Macara IG (Apr 1995). "The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif". Proceedings of the National Academy of Sciences of the United States of America. 92 (8): 3328-32. 2. Yaseen NR, Blobel G (Sep 1999). "GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358". The Journal of Biological Chemistry. 274 (37): 26493-502. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
-
-
- RANBP2 (RAN Binding Protein 2 (RANBP2))
-
别名
- RANBP2
-
背景
-
Synonyms: E3 SUMO-protein ligase RanBP2,6.3.2.-,358 kDa nucleoporin,Nuclear pore complex protein Nup358,Nucleoporin Nup358,Ran-binding protein 2,RanBP2,p270,RANBP2,NUP358,
Tissue Specificity: Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.
Background: RAN binding protein 2 (RANBP2) is protein which in humans is encoded by the RANBP2 gene. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. And the encoded protein ly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q.
-
分子量
- 358 kDa
-
基因ID
- 5903
-
UniProt
- P49792
-
途径
- Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
抗原
-
