MBNL1 抗体 (AA 89-388)
Quick Overview for MBNL1 抗体 (AA 89-388) (ABIN7602608)
抗原
See all MBNL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 89-388
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原理
- Anti-MBNL1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-MBNL1 Antibody Picoband® (ABIN7602608). Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MBNL1 recombinant protein (Position: Q89-M388).
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亚型
- IgG
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anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-382) antibody
MBNL1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E7 unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-383) antibodyMBNL1 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E7 unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (Middle Region) antibodyMBNL1 适用: 人, 大鼠, 小鼠, 犬, 马, Pig, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (C-Term) antibodyMBNL1 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-382) antibodyMBNL1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-343) antibodyMBNL1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D11 unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (AA 211-260) antibodyMBNL1 适用: 人, 大鼠, 犬, 马, Pig, 兔, 斑马鱼, 猴, Bat, 小鸡, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) (AA 1-382) antibodyMBNL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) antibodyMBNL1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Muscleblind-like Protein 1 (MBNL1) antibodyMBNL1 适用: 人, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Monkey, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Fardaei, M., Rogers, M. T., Thorpe, H. M., Larkin, K., Hamshere, M. G., Harper, P. S., Brook, J. D. Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells. Hum. Molec. Genet. 11: 805-814, 2002. 2. Freyermuth, F., Rau, F., Kokunai, Y., Linke, T., Sellier, C., Nakamori, M., Kino, Y., Arandel, L., Jollet, A., Thibault, C., Philipps, M., Vicaire, S., and 31 others. Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy. Nat. Commun. 7: 11067, 2016. Note: Electronic Article. 3. Han, H., Irimia, M., Ross, P. J., Sung, H.-K., Alipanahi, B., David, L., Golipour, A., Gabut, M., Michael, I. P., Nachman, E. N., Wang, E., Trcka, D., and 11 others. MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature 498: 241-245, 2013. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- MBNL1 (Muscleblind-like Protein 1 (MBNL1))
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别名
- MBNL1
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背景
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Synonyms: Muscleblind-like protein 1, Triplet-expansion RNA-binding protein, MBNL1, EXP, KIAA0428, MBNL
Tissue Specificity: Highly expressed in cardiac, skeletal muscle and during myoblast differentiation. Weakly expressed in other tissues (at protein level). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Background: Muscleblind-like (Drosophila), also known as MBNL1, is a protein that in humans is encoded by the MBNL1 gene. It is mapped to 3q25.1-q25.2. This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.
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分子量
- 40 kDa
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基因ID
- 4154
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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