PYHIN1 抗体 (AA 86-488)
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- 抗原 See all PYHIN1 抗体
- PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))
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抗原表位
- AA 86-488
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PYHIN1 antibody is un-conjugated
- 应用范围
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- 原理
- Anti-PYHIN1 Antibody Picoband®
- 产品特性
- Anti-PYHIN1 Antibody Picoband® (ABIN7602574). Tested in WB, IHC, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human PYHIN1 recombinant protein (Position: K86-H488). Human PYHIN1 shares 45.6% amino acid (aa) sequence identity with mouse PYHIN1.
- Top Product
- Discover our top product PYHIN1 Primary Antibody
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anti-Pyrin and HIN Domain Family, Member 1 (PYHIN1) (AA 26-55), (N-Term) antibody
PYHIN1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB26421 unconjugated
anti-Pyrin and HIN Domain Family, Member 1 (PYHIN1) (AA 1-245) antibodyPYHIN1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Pyrin and HIN Domain Family, Member 1 (PYHIN1) (N-Term) antibodyPYHIN1 适用: 人, 小鼠, 大鼠, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry, 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ding, Y., Lee, J.-F., Lu, H., Lee, M.-H., Yan, D.-H. Interferon-inducible protein IFIX-alpha-1 functions as a negative regulator of HDM2. Molec. Cell. Biol. 26: 1979-1996, 2006. 2. Ding, Y., Wang, L., Su, L.-K., Frey, J. A., Shao, R., Hunt, K. K., Yan, D.-H. Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer. Oncogene 23: 4556-4566, 2004. 3. Yamaguchi, H., Ding, Y., Lee, J.-F., Zhang, M., Pal, A., Bornmann, W., Yan, D.-H., Hung, M.-C. Interferon-inducible protein IFIX-alpha inhibits cell invasion by upregulating the metastasis suppressor maspin. Molec. Carcinogen. 47: 739-743, 2008. - 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- 抗原
- PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))
- 别名
- PYHIN1 (PYHIN1 产品)
- 背景
- The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
- 分子量
- 55 kDa
- 基因ID
- 149628
- UniProt
- Q6K0P9
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