MESDC2 抗体 (AA 80-205)
Quick Overview for MESDC2 抗体 (AA 80-205) (ABIN7602508)
抗原
See all MESDC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 80-205
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原理
- Anti-MESDC2/MESD Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-MESDC2/MESD Antibody Picoband® (ABIN7602508). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MESDC2/MESD recombinant protein (Position: D80-Q205).
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亚型
- IgG
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anti-Mesoderm Development Candidate 2 (MESDC2) (AA 1-234) antibody
MESDC2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mesoderm Development Candidate 2 (MESDC2) (AA 203-234), (C-Term) antibodyMESDC2 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Mesoderm Development Candidate 2 (MESDC2) antibodyMESDC2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Mesoderm Development Candidate 2 (MESDC2) (Internal Region) antibodyMESDC2 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mesoderm Development Candidate 2 (MESDC2) (AA 1-234) antibodyMESDC2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Culi, J., Mann, R. S. Boca, an endoplasmic reticulum protein required for Wingless signaling and trafficking of LDL receptor family members in Drosophila. Cell 112: 343-354, 2003. 2. Gross, M. B. Personal Communication. Baltimore, Md. 10/15/2019. 3. Hsieh, J.-C., Lee, L., Zhang, L., Wefer, S., Brown, K., DeRossi, C., Wines, M. E., Rosenquist, T., Holdener, B. C. Mesd encodes the LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell 112: 355-367, 2003. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- MESDC2 (Mesoderm Development Candidate 2 (MESDC2))
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别名
- MESD
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背景
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Synonyms: Protein Bop, BH3-only protein, Retrotransposon Gag-like protein 10, RTL10, BOP, C22orf29
Tissue Specificity: Ubiquitously expressed.
Background: Mesoderm development candidate genes 1 (MESDC1) and 2 (MESDC2) were identified from the mesoderm development (MESD) deletion interval located on mouse chromosome 7. MESD acts as a chaperone for low-density lipoprotein receptor (LDLR) proteins in the ER, and particularly associates with Wnt signaling pathway coreceptors LRP5 and LPR6. MESD is required for proper LRP5/6 folding and maturation to the cell surface, which plays a major role in Wnt signaling. The interaction between MESD and LRP5 is disrupted by a G171V mutation in LRP5 that is found in individuals with a familial phenotype characterized by high bone mass.
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分子量
- 24 kDa
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基因ID
- 23184
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UniProt
- Q14696
抗原
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