RASGRP1 抗体 (AA 8-678)
Quick Overview for RASGRP1 抗体 (AA 8-678) (ABIN7602498)
抗原
See all RASGRP1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 8-678
-
原理
- Anti-RASGRP1 Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-RASGRP1 Antibody Picoband® (ABIN7602498). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human RASGRP1 recombinant protein (Position: R8-Q678).
-
亚型
- IgG
-
-
anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (AA 598-797) antibody
RASGRP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (AA 495-521) antibodyRASGRP1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21940 unconjugated
anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (AA 594-716) antibodyRASGRP1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (AA 617-666) antibodyRASGRP1 适用: 人, 豚鼠, 小鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bivona, T. G., Perez de Castro, I., Ahearn, I. M., Grana, T. M., Chiu, V. K., Lockyer, P. J., Cullen, P. J., Pellicer, A., Cox, A. D., Philips, M. R. Phospholipase C-gamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature 424: 694-698, 2003. 2. Bottorff, D., Ebinu, J., Stone, J. C. RasGRP, a Ras activator: mouse and human cDNA sequences and chromosomal positions. Mammalian Genome 10: 358-361, 1999. 3. Ebinu, J. O., Bottorff, D. A., Chan, E. Y. W., Stang, S. L., Dunn, R. J., Stone, J. C. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science 280: 1082-1086, 1998. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
-
-
- RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))
-
别名
- RASGRP1
-
背景
-
Synonyms: Endoglin, Cell surface MJ7/18 antigen, CD105, Eng, Edg,
Background: RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene. This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
-
分子量
- 100 kDa
-
基因ID
- 10125
-
UniProt
- O95267
-
途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
抗原
-
