GCKR 抗体 (AA 8-569)
Quick Overview for GCKR 抗体 (AA 8-569) (ABIN7602493)
抗原
See all GCKR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 8-569
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原理
- Anti-GCKR Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-GCKR Antibody Picoband® (ABIN7602493). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human GCKR recombinant protein (Position: Q8-Q569).
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亚型
- IgG
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anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (AA 17-261) antibody
GCKR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (AA 90-286) antibodyGCKR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (AA 1-625) antibodyGCKR 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (AA 1-214) antibodyGCKR 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glucokinase (Hexokinase 4) Regulator (GCKR) antibodyGCKR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Glucokinase (Hexokinase 4) Regulator (GCKR) antibodyGCKR 适用: 人 WB, IHC, IF 宿主: 小鼠 Monoclonal 1E7 unconjugated
anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (AA 121-220) antibodyGCKR 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (AA 87-120) antibodyGCKR 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal RB53063 unconjugated
anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (AA 90-286) antibodyGCKR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 4# unconjugated
anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (AA 40-72) antibodyGCKR 适用: 人 WB 宿主: 兔 Polyclonal RB53114 unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Beer, N. L., Tribble, N. D., McCulloch, L. J., Roos, C., Johnson, P. R. V., Orho-Melander, M., Gloyn, A. L. The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum. Molec. Genet. 18: 4081-4088, 2009. 2. Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Magi, R., and 295 others. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genet. 42: 105-116, 2010. Note: Erratum: Nature Genet. 42: 464 only, 2010. 3. Farrelly, D., Brown, K. S., Tieman, A., Ren, J., Lira, S. A., Hagan, D., Gregg, R., Mookhtiar, K. A., Hariharan, N. Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation. Proc. Nat. Acad. Sci. 96: 14511-14516, 1999. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- GCKR (Glucokinase (Hexokinase 4) Regulator (GCKR))
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别名
- GCKR
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背景
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Synonyms: Carnitine O-palmitoyltransferase 2, mitochondrial, Carnitine palmitoyltransferase II, CPT II, CPT2, CPT1
Tissue Specificity: Expressed mainly in adipose tissues.
Background: The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
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分子量
- 69 kDa
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基因ID
- 2646
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UniProt
- Q14397
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途径
- Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
抗原
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