Aminoacylase 1 抗体 (AA 8-354)
Quick Overview for Aminoacylase 1 抗体 (AA 8-354) (ABIN7602484)
抗原
See all Aminoacylase 1 (ACY1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 8-354
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原理
- Anti-ACY-1/ACY1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-ACY-1/ACY1 Antibody Picoband® (ABIN7602484). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human ACY-1/ACY1 recombinant protein (Position: E8-A354).
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亚型
- IgG
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anti-Aminoacylase 1 (ACY1) (AA 1-408) antibody
ACY1 适用: 人 WB, ELISA, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 4F1-B7 unconjugated
anti-Aminoacylase 1 (ACY1) (AA 2-408) antibodyACY1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aminoacylase 1 (ACY1) antibodyACY1 适用: 人, 小鼠, 大鼠, 犬 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 2D3 unconjugated
anti-Aminoacylase 1 (ACY1) antibodyACY1 适用: 人, 犬, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Aminoacylase 1 (ACY1) (AA 1-408) antibodyACY1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Aminoacylase 1 (ACY1) (AA 1-408) antibodyACY1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Aminoacylase 1 (ACY1) antibodyACY1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Aminoacylase 1 (ACY1) (AA 1-408) antibodyACY1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Aminoacylase 1 (ACY1) (AA 1-409) antibodyACY1 适用: 人 WB, IHC, ELISA, IF, IP, IHC (p) 宿主: 小鼠 Monoclonal 4F1-B7 unconjugated
anti-Aminoacylase 1 (ACY1) antibodyACY1 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Boldog, F., Erlandsson, R., Klein, G., Sumegi, J. Long-range restriction enzyme maps of DNF15S2, D3S2 and c-raf1 loci on the short arm of human chromosome 3. Cancer Genet. Cytogenet. 42: 295-306, 1989. 2. Cook, R. M., Burke, B. J., Buchhagen, D. L., Minna, J. D., Miller, Y. E. Human aminoacylase-1: cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer. J. Biol. Chem. 268: 17010-17017, 1993. 3. Ferri, L., Funghini, S., Fioravanti, A., Biondi, E. G., la Marca, G., Guerrini, R., Donati, M. A., Morrone, A. Aminoacylase I deficiency due to ACY1 mRNA exon skipping. Clin. Genet. 86: 367-372, 2014. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Aminoacylase 1 (ACY1)
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别名
- ACY1
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背景
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Synonyms: N-alpha-acetyltransferase 15, NatA auxiliary subunit,Gastric cancer antigen Ga19,N-terminal acetyltransferase,NMDA receptor-regulated protein 1,Protein tubedown-1,Tbdn100,NAA15,GA19, NARG1, NATH, TBDN100,
Tissue Specificity: Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy. .
Background: Aminoacylase-1 is an enzyme that in humans is encoded by the ACY1 gene. This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.
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分子量
- 40-43 kDa
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基因ID
- 95
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UniProt
- Q03154
抗原
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