HSD17B2 抗体 (AA 75-365)
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北京 101111
Quick Overview for HSD17B2 抗体 (AA 75-365) (ABIN7602416)
抗原
See all HSD17B2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 75-365
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原理
- Anti-HSD17B2 Antibody
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交叉反应 （详细）
- No cross reactivity with other proteins.
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预测反应
- Human HSD17B2 shares 63.6%,65.2% amino acid (aa) sequence identity with mouse,rat HSD17B2,respectively.
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产品特性
- Anti-HSD17B2 Antibody. Tested in ELISA, IF, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human HSD17B2 recombinant protein (Position: Q75-R365). Human HSD17B2 shares 63.6% and 65.2% amino acid (aa) sequence identity with mouse and rat HSD17B2, respectively.
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亚型
- IgG
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anti-Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2) (AA 118-387) antibody
HSD17B2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2) (AA 1-387) antibodyHSD17B2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2) antibodyHSD17B2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2) (C-Term) antibodyHSD17B2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2) (AA 265-294) antibodyHSD17B2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB26219 unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2) (AA 373-387) antibodyHSD17B2 适用: 人 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2) (AA 1-387) antibodyHSD17B2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2) (AA 118-387) antibodyHSD17B2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2) (AA 151-250) antibodyHSD17B2 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2) (C-Term) antibodyHSD17B2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot, 0.25-0.5 μg/mL, Human, Mouse Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human ELISA, 0.1-0.5 μg/mL, -
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing. -
有效期
- 12 months
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- HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))
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别名
- HSD17B2
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背景
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Background: HSD17B2(17-BETA-HYDROXYSTEROID DEHYDROGENASE II), also called 17-BETA-HSD II, is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum. Its Cytogenetic location is 16q23.3. The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42(43 % ) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And HSD17B2 activity distinguishing between disease-free and diseased endometria. HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.
Gene Full Name: hydroxysteroid 17-beta dehydrogenase 2
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分子量
- 37 kDa
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基因ID
- 3294
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UniProt
- P37059
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途径
- Steroid Hormone Biosynthesis
抗原
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