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Meprin B 抗体 (AA 73-489)

MEP1B 适用: 大鼠, 人, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7602389
发货至: 中国
  • 抗原 See all Meprin B (MEP1B) 抗体
    Meprin B (MEP1B) (Meprin A, beta (MEP1B))
    抗原表位
    • 1
    • 1
    • 1
    AA 73-489
    适用
    大鼠, 人, 小鼠
    宿主
    • 4
    克隆类型
    • 4
    多克隆
    标记
    • 4
    This Meprin B antibody is un-conjugated
    应用范围
    • 4
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
    原理
    Anti-MEP1B Antibody Picoband®
    产品特性
    Anti-MEP1B Antibody Picoband® (ABIN7602389). Tested in WB, IF, IHC, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    E.coli-derived human MEP1B recombinant protein (Position: H73-Q489). Human MEP1B shares 82.3% and 81.5% amino acid (aa) sequence identity with mouse and rat MEP1B, respectively.
    Top Product
    Discover our top product MEP1B Primary Antibody
  • 应用备注
    Western blot, 0.25-0.5 μg/mL, Mouse, Rat
    Immunohistochemistry, 2-5 μg/mL, Mouse, Rat
    Immunofluorescence, 5 μg/mL, Mouse, Rat
    ELISA, 0.1-0.5 μg/mL, -
    1. Bond, J. S., Rojas, K., Overhauser, J., Zoghbi, H. Y., Jiang, W. The structural genes, MEP1A and MEP1B, for the alpha and beta subunits of the metalloendopeptidase meprin map to human chromosomes 6p and 18q, respectively. Genomics 25: 300-303, 1995. 2. Crisman, J. M., Zhang, B., Norman, L. P., Bond, J. S. Deletion of the mouse meprin beta metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix. J. Immun. 172: 4510-4519, 2004. 3. Gorbea, C. M., Marchand, P., Jiang, W., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Bond, J. S. Cloning, expression, and chromosomal localization of the mouse meprin beta subunit. J. Biol. Chem. 268: 21035-21043, 1993.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    储存条件
    4 °C,-20 °C
    储存方法
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • 抗原
    Meprin B (MEP1B) (Meprin A, beta (MEP1B))
    别名
    MEP1B (MEP1B 产品)
    背景
    Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene. Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
    分子量
    97 kDa
    基因ID
    4225
    UniProt
    Q16820
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