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MAEL 抗体 (AA 73-347)

MAEL 适用: 人 ELISA, WB, FACS 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7602386
发货至: 中国
  • 抗原 See all MAEL 抗体
    MAEL (Maelstrom Spermatogenic Transposon Silencer (MAEL))
    抗原表位
    • 5
    • 2
    • 1
    AA 73-347
    适用
    • 7
    • 1
    • 1
    宿主
    • 7
    克隆类型
    • 7
    多克隆
    标记
    • 3
    • 2
    • 1
    • 1
    This MAEL antibody is un-conjugated
    应用范围
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Flow Cytometry (FACS)
    原理
    Anti-MAEL Antibody Picoband®
    交叉反应 (详细)
    No cross-reactivity with other proteins.
    产品特性
    Anti-MAEL Antibody Picoband® (ABIN7602386). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    E.coli-derived human MAEL recombinant protein (Position: E73-Q347).
    亚型
    IgG
    Top Product
    Discover our top product MAEL Primary Antibody
  • 应用备注
    Western blot, 0.25-0.5 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Findley, S. D., Tamanaha, M., Clegg, N. J., Ruohola-Baker, H. Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage. Development 130: 859-871, 2003. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 7/29/2009. 3. Soper, S. F. C., van der Heijden, G. W., Hardiman, T. C., Goodheart, M., Martin, S. L., de Boer, P., Bortvin, A. Mouse Maelstrom, a component of nuage, is essential for spermatogenesis and transposon regression in meiosis. Dev. Cell 15: 285-297, 2008. [PubMed: 18694567, images, related citations] [Full Text]
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    储存条件
    4 °C,-20 °C
    储存方法
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • 抗原
    MAEL (Maelstrom Spermatogenic Transposon Silencer (MAEL))
    别名
    MAEL (MAEL 产品)
    背景

    Synonyms: FERM domain-containing protein 6, Willin, FRMD6, C14orf31

    Tissue Specificity: Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

    Background: The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatoid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.

    分子量
    49 kDa
    基因ID
    84944
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