Triadin 抗体 (AA 67-729)
Quick Overview for Triadin 抗体 (AA 67-729) (ABIN7602275)
抗原
See all Triadin (TRDN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 67-729
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原理
- Anti-Triadin/TRDN Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Triadin/TRDN Antibody Picoband® (ABIN7602275). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Triadin/TRDN recombinant protein (Position: M67-Q729).
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亚型
- IgG
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anti-Triadin (TRDN) (AA 486-687) antibody
TRDN 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Triadin (TRDN) (AA 344-693) antibodyTRDN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Triadin (TRDN) (AA 75-161) antibodyTRDN 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Altmann, H. M., Tester, D. J., Will, M. L., Middha, S., Evans, J. M., Eckloff, B. W., Ackerman, M. J. Homozygous/compound heterozygous triadin mutations associated with autosomal-recessive long-QT syndrome and pediatric sudden cardiac arrest: elucidation of the triadin knockout syndrome. Circulation 131: 2051-2060, 2015. 2. Chopra, N., Yang, T., Asghari, P., Moore, E. D., Huke, S., Akin, B., Cattolica, R. A., Perez, C. F., Hlaing, T., Knollmann-Ritschel, B. E. C., Jones, L. R., Pessah, I. N., Allen, P. D., Franzini-Armstrong, C., Knollmann, B. C. Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proc. Nat. Acad. Sci. 106: 7636-7641, 2009. 3. Hong, C.-S., Ji, J.-H., Kim, J. P., Jung, D. H., Kim, D. H. Molecular cloning and characterization of mouse cardiac triadin isoforms. Gene 278: 193-199, 2001. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Triadin (TRDN)
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别名
- TRDN
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背景
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Synonyms: Disintegrin and metalloproteinase domain-containing protein 28,ADAM 28,3.4.24.-,Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II,eMDC II,Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L,MDC-L,ADAM28,ADAM23, MDCL,
Tissue Specificity: Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen.
Background: This gene encodes an integral membrane protein found in skeletal and cardiac muscle. The encoded protein plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex and is required for normal skeletal muscle strength. This protein inly links triads and microtubules in skeletal muscle. Mutations in this gene are associated with cardiac arrythmia syndrome and some variants in this gene may be associated with sudden cardiac death.
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分子量
- 25 kDa
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基因ID
- 10345
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UniProt
- Q13061
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途径
- Negative Regulation of Transporter Activity
抗原
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