NCOA6 抗体 (AA 64-1475)
Quick Overview for NCOA6 抗体 (AA 64-1475) (ABIN7602210)
抗原
See all NCOA6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 64-1475
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原理
- Anti-NCOA6 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-NCOA6 Antibody Picoband® (ABIN7602210). Tested in WB, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human NCOA6 recombinant protein (Position: K64-E1475). Human NCOA6 shares 92.1% amino acid (aa) sequence identity with mouse NCOA6.
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亚型
- IgG
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anti-Nuclear Receptor Coactivator 6 (NCOA6) (AA 1954-2063) antibody
NCOA6 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 2D7 unconjugated
anti-Nuclear Receptor Coactivator 6 (NCOA6) (AA 285-504) antibodyNCOA6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL
1. Antonson, P., Jakobsson, T., Almlof, T., Guldevall, K., Steffensen, K. R., Gustafsson, J.-A. RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. J. Biol. Chem. 283: 8995-9001, 2008. 2. Antonson, P., Schuster, G. U., Wang, L., Rozell, B., Holter, E., Flodby, P., Treuter, E., Holmgren, L., Gustafsson, J.-A. Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Molec. Cell. Biol. 23: 1260-1268, 2003. 3. Caira, F., Antonson, P., Pelto-Huikko, M., Treuter, E., Gustafsson, J.-A. Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J. Biol. Chem. 275: 5308-5317, 2000. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- NCOA6 (Nuclear Receptor Coactivator 6 (NCOA6))
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别名
- NCOA6
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背景
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Synonyms: NCOA6, AIB3, KIAA0181, RAP250, TRBP, Nuclear receptor coactivator 6, Activating signal cointegrator 2, ASC-2, Amplified in breast cancer protein 3, Cancer-amplified transcriptional coactivator ASC-2, Nuclear receptor coactivator RAP250, NRC RAP250, Nuclear receptor-activating protein, 250 kDa, Peroxisome proliferator-activated receptor-interacting protein, PPAR-interacting protein, PRIP, Thyroid hormone receptor-binding protein
Background: The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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分子量
- 250 kDa
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基因ID
- 23054
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UniProt
- Q14686
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
抗原
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