Androgen Receptor 抗体 (AA 629-920)
Quick Overview for Androgen Receptor 抗体 (AA 629-920) (ABIN7602200)
抗原
See all Androgen Receptor (AR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 629-920
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原理
- Anti-Androgen Receptor/AR Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Androgen Receptor/AR Antibody Picoband® (ABIN7602200). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Androgen Receptor/AR recombinant protein (Position: A629-Q920).
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亚型
- IgG
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anti-Androgen Receptor (AR) antibody
AR 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Androgen Receptor (AR) (N-Term) antibodyAR 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Androgen Receptor (AR) antibodyAR 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 2H8 unconjugated
anti-Androgen Receptor (AR) antibodyAR 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Androgen Receptor (AR) (AA 491-679) antibodyAR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C4 unconjugated
anti-Androgen Receptor (AR) (N-Term) antibodyVerified AR 适用: 人 WB, IHC, ELISA, IF, ChIP 宿主: 山羊 Polyclonal unconjugated
anti-Androgen Receptor (AR) (AA 221-320) antibodyAR 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 1G3 unconjugated
anti-Androgen Receptor (AR) (AA 15-246) antibodyAR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Androgen Receptor (AR) (AA 365-392) antibodyAR 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Androgen Receptor (AR) (AA 825-919) antibodyAR 适用: 人, 小鼠, 大鼠, Pig, 山羊 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Wilson, J. D.The promiscuous receptor: prostate cancer comes of age. (Editorial)New Eng. J. Med. 332: 1440-1441, 1995. 2. Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X.-M., Lardy, H., Huang, K.-E., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., Xing, L., Boyce, B. F., Hung, M.-C., Zhang, S., Gan, L., Chang, C.Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues.Proc. Nat. Acad. Sci. 99: 13498-13503, 2002. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Androgen Receptor (AR)
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别名
- AR
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背景
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Synonyms: Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR, DHTR, NR3C4
Tissue Specificity: Isoform 2 is mainly expressed in heart and skeletal muscle. Isoform 3 is expressed by basal and stromal cells of prostate.
Background: The AR (androgen receptor) gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The AR gene is mapped to Xq12. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
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分子量
- 120 kDa
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基因ID
- 367
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UniProt
- P10275
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途径
- Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
抗原
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