EXOSC2 抗体 (AA 62-293)
Quick Overview for EXOSC2 抗体 (AA 62-293) (ABIN7602188)
抗原
See all EXOSC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 62-293
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原理
- Anti-RRP4/EXOSC2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-RRP4/EXOSC2 Antibody Picoband® (ABIN7602188). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human RRP4/EXOSC2 recombinant protein (Position: R62-G293).
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亚型
- IgG
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anti-Exosome Component 2 (EXOSC2) (AA 1-293) antibody
EXOSC2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 2 (EXOSC2) (AA 1-293) antibodyEXOSC2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 2 (EXOSC2) (AA 71-160) antibodyEXOSC2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Exosome Component 2 (EXOSC2) (N-Term) antibodyEXOSC2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 2 (EXOSC2) (AA 71-160) antibodyEXOSC2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4B6 unconjugated
anti-Exosome Component 2 (EXOSC2) (N-Term) antibodyEXOSC2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 2 (EXOSC2) (AA 143-192) antibodyEXOSC2 适用: 人, 小鼠, 犬, Cow, 豚鼠, 马, Pig, 兔, 猴, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 2 (EXOSC2) (AA 1-30), (N-Term) antibodyEXOSC2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 2 (EXOSC2) (Middle Region) antibodyEXOSC2 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chen, C.-Y., Gherzi, R., Ong, S.-E., Chan, E. L., Raijmakers, R., Pruijn, G. J. M., Stoecklin, G., Moroni, C., Mann, M., Karin, M. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 107: 451-464, 2001. 2. Di Donato, N., Neuhann, T., Kahlert, A.-K., Klink, B., Hackmann, K., Neuhann, I., Novotna, B., Schallner, J., Krause, C., Glass, I. A., Parnell, S. E., Genet-Pages, A., and 9 others. Mutations in EXOSC2 are associated with a novel syndrome characterised by retinitis pigmentosa, progressive hearing loss, premature ageing, short stature, mild intellectual disability and distinctive gestalt. J. Med. Genet. 53: 419-425, 2016. 3. Gross, M. B. Personal Communication. Baltimore, Md. 6/25/2014. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- EXOSC2 (Exosome Component 2 (EXOSC2))
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别名
- EXOSC2
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背景
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Synonyms: Protein NDRG3,N-myc downstream-regulated gene 3 protein,NDRG3,
Tissue Specificity: Ubiquitous. Highly expressed in brain. .
Background: Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snoRNA and snRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. EXOSC2 is a non-catalytic component of the RNA exosome complex that has 3'->5' exoribonuclease activity and involves in a multitude of cellular RNA processing and degradation events.
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分子量
- 33 kDa
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基因ID
- 23404
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UniProt
- Q13868
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途径
- SARS-CoV-2 Protein Interactome
抗原
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