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POLR1A 抗体 (AA 607-1720)

POLR1A 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7602161
发货至: 中国
  • 抗原 See all POLR1A 抗体
    POLR1A (Polymerase (RNA) I Polypeptide A, 194kDa (POLR1A))
    抗原表位
    • 9
    • 2
    • 1
    • 1
    • 1
    AA 607-1720
    适用
    • 13
    • 1
    • 1
    • 1
    宿主
    • 13
    克隆类型
    • 13
    多克隆
    标记
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    This POLR1A antibody is un-conjugated
    应用范围
    • 12
    • 8
    • 2
    Western Blotting (WB), ELISA
    原理
    Anti-POLR1A Antibody Picoband®
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-POLR1A Antibody Picoband® (ABIN7602161). Tested in WB, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    E.coli-derived human POLR1A recombinant protein (Position: E607-R1720). Human POLR1A shares 86.3% and 87.3% amino acid (aa) sequence identity with mouse and rat POLR1A, respectively.
    亚型
    IgG
    Top Product
    Discover our top product POLR1A Primary Antibody
  • 应用备注
    Western blot, 0.25-0.5 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL
    1. da Rocha, L. A., Pires, L. V. L., Yamamoto, G. L., Magliocco Ceroni, J. R., Honjo, R. S., de Novaes Franca Bisneto, E., Oliveira, L. A. N., Rosenberg, C., Krepischi, A. C. V., Passos-Bueno, M. R., Kim, C. A., Bertola, D. R. Congenital limb deficiency: genetic investigation of 44 individuals presenting mainly longitudinal defects in isolated or syndromic forms. Clin. Genet. 100: 615-623, 2021. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 6/2/2015. 3. Kara, B., Koroglu, C., Peltonen, K., Steinberg, R., Maras Genc, H., Holtta-Vuori, M., Guven, A., Kanerva, K., Kotil, T., Solakoglu, S., Zhou, Y., Olkkonen, V. M., Ikonen, E., Laiho, M., Tolun, A. Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A. Europ. J. Hum. Genet. 25: 315-323, 2017.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
    储存条件
    4 °C,-20 °C
    储存方法
    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • 抗原
    POLR1A (Polymerase (RNA) I Polypeptide A, 194kDa (POLR1A))
    别名
    POLR1A (POLR1A 产品)
    背景

    Synonyms: POLR1A, DNA-directed RNA polymerase I subunit RPA1, RNA polymerase I subunit A1, EC 2.7.7.6, A190, DNA-directed RNA polymerase I largest subunit, DNA-directed RNA polymerase I subunit A, RNA polymerase I 194 kDa subunit, RPA194

    Background: DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene. The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis.

    分子量
    195 kDa
    基因ID
    25885
    UniProt
    O95602
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