R-Spondin 4 抗体 (AA 60-206)
Quick Overview for R-Spondin 4 抗体 (AA 60-206) (ABIN7602151)
抗原
See all R-Spondin 4 (RSPO4) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 60-206
-
原理
- Anti-RSPO4 Antibody Picoband®
-
交叉反应 （详细）
- No cross reactivity with other proteins.
-
产品特性
- Anti-RSPO4 Antibody Picoband® (ABIN7602151). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human RSPO4 recombinant protein (Position: R60-K206). Human RSPO4 shares 82.2% amino acid (aa) sequence identity with mouse RSPO4.
-
亚型
- IgG
-
-
anti-R-Spondin 4 (RSPO4) (AA 199-228), (C-Term) antibody
RSPO4 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB26928 unconjugated
-
-
应用备注
-
Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bergmann, C., Senderek, J., Anhuf, D., Thiel, C. T., Ekici, A. B., Poblete-Gutierrez, P., van Steensel, M., Seelow, D., Nurnberg, G., Schild, H. H., Nurnberg, P., Reis, A., Frank, J., Zerres, K. Mutations in the gene encoding the Wnt-signaling component R-spondin 4 (RSPO4) cause autosomal recessive anonychia. Am. J. Hum. Genet. 79: 1105-1109, 2006. 2. Blaydon, D. C., Ishii, Y., O'Toole, E. A., Unsworth, H. C., Teh, M.-T., Ruschendorf, F., Sinclair, C., Hopsu-Havu, V. K., Tidman, N., Moss, C., Watson, R., de Berker, D., Wajid, M., Christiano, A. M., Kelsell, D. P. The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. Nature Genet. 38: 1245-1247, 2006. 3. Bruchle, N. O., Frank, J., Frank, V., Senderek, J., Akar, A., Koc, E., Rigopoulos, D., van Steensel, M., Zerres, K., Bergmann, C. RSPO4 is the major gene in autosomal-recessive anonychia and mutations cluster in the furin-like cysteine-rich domains of the Wnt signaling ligand R-spondin 4. J. Invest. Derm. 128: 791-796, 2008. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
-
-
- R-Spondin 4 (RSPO4)
-
别名
- RSPO4
-
背景
-
Synonyms: 70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70 kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Tissue Specificity: Expressed in all tissues.
Background: For chromosome 20, R-spondin 4 is a protein in humans that is encoded by the RSPO4 gene. This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.
-
分子量
- 26 kDa
-
基因ID
- 343637
-
UniProt
- Q2I0M5
抗原
-
