DRD4 抗体 (AA 57-387)
Quick Overview for DRD4 抗体 (AA 57-387) (ABIN7602065)
抗原
See all DRD4 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 57-387
-
原理
- Anti-DRD4 Antibody Picoband®
-
交叉反应 (详细)
- No cross-reactivity with other proteins.
-
产品特性
- Anti-DRD4 Antibody Picoband® (ABIN7602065). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived mouse DRD4 recombinant protein (Position: A57-C387).
-
亚型
- IgG
-
-
-
-
应用备注
-
Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Mouse
ELISA, 0.1-0.5 μg/mL,
1. D'Souza, U. M., Russ, C., Tahir, E., Mill, J., McGuffin, P., Asherson, P. J., Craig, I. W. Functional effects of a tandem duplication polymorphism in the 5-prime flanking region of the DRD4 gene. Biol. Psychiat. 56: 691-697, 2004. 2. De Luca, A., Rizzardi, M., Buccino, A., Alessandroni, R., Salvioli, G. P., Filograsso, N., Novelli, G., Dallapiccola, B. Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants. Neurogenetics 4: 207-212, 2003. 3. De Luca, A., Rizzardi, M., Torrente, I., Alessandroni, R., Salvioli, G. P., Filograsso, N., Dallapiccola, B., Novelli, G. Dopamine D4 receptor (DRD4) polymorphism and adaptability trait during infancy: a longitudinal study in 1- to 5-month-old neonates. Neurogenetics 3: 79-82, 2001. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
-
-
- DRD4 (Dopamine Receptor D4 (DRD4))
-
别名
- Drd4
-
背景
-
Synonyms: D (4) dopamine receptor; D (2C) dopamine receptor; Dopamine D4 receptor; Drd4
Tissue Specificity: Found only in peripheral nervous system Schwann cells.
Background: D (4) dopamine receptor is a protein that in humans is encoded by the Drd4 gene. This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. And this subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
-
分子量
- 48 kDa
-
基因ID
- 13491
-
UniProt
- P51436
-
途径
- cAMP Metabolic Process, Synaptic Membrane, Proton Transport, Photoperiodism, Negative Regulation of Transporter Activity
抗原
-