OS9 抗体 (AA 56-635)
Quick Overview for OS9 抗体 (AA 56-635) (ABIN7602048)
抗原
See all OS9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 56-635
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原理
- Anti-OS9 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-OS9 Antibody Picoband® (ABIN7602048). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human OS9 recombinant protein (Position: Q56-E635).
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亚型
- IgG
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anti-Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) (AA 232-413) antibody
OS9 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) (AA 465-666) antibodyOS9 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) (AA 1-612) antibodyOS9 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) (Internal Region) antibodyOS9 适用: 人, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) (AA 466-667) antibodyOS9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) (AA 471-672) antibodyOS9 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) (AA 353-612) antibodyOS9 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) (AA 300-400), (Isoform 1) antibodyOS9 适用: 人, 小鼠 WB, IHC, IP, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Baek, J. H., Mahon, P. C., Oh, J., Kelly, B., Krishnamachary, B., Pearson, M., Chan, D. A., Giaccia, A. J., Semenza, G. L. OS-9 interacts with hypoxia-inducible factor 1-alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1-alpha. Molec. Cell 17: 503-512, 2005. 2. Bhamidipati, A., Denic, V., Quan, E. M., Weissman, J. S. Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. Molec. Cell 19: 741-751, 2005. 3. Friedmann, E., Salzberg, Y., Weinberger, A., Shaltiel, S., Gerst, J. E. YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins. J. Biol. Chem. 277: 35274-35281, 2002. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- OS9 (Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9))
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别名
- OS9
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背景
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Synonyms: Eukaryotic peptide chain release factor subunit 1, Eukaryotic release factor 1, Erf1, Protein Cl1, TB3-1, ETF1, ERF1, RF1, SUP45L1
Tissue Specificity: Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.
Background: Protein OS-9 is a protein that in humans is encoded by the OS9 gene. This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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分子量
- 83 kDa
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基因ID
- 10956
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UniProt
- Q13438
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途径
- Maintenance of Protein Location, SARS-CoV-2 Protein Interactome
抗原
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