CBX1 抗体 (AA 55-185)
Quick Overview for CBX1 抗体 (AA 55-185) (ABIN7602012)
抗原
See all CBX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 55-185
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原理
- Anti-CBX1/HP1 beta Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-CBX1/HP1 Antibody Picoband® (ABIN7602012). Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CBX1/HP1 beta recombinant protein (Position: E55-N185).
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亚型
- IgG
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anti-Chromobox Homolog 1 (CBX1) (AA 1-185) antibody
CBX1 适用: 人 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 4D7B8 unconjugated
anti-Chromobox Homolog 1 (CBX1) (Center) antibodyCBX1 适用: 人, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromobox Homolog 1 (CBX1) (AA 2-99) antibodyCBX1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E12 unconjugated
anti-Chromobox Homolog 1 (CBX1) (Internal Region) antibodyVerified CBX1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Chromobox Homolog 1 (CBX1) (AA 1-185) antibodyCBX1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromobox Homolog 1 (CBX1) (AA 128-155), (C-Term) antibodyCBX1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23535 unconjugated
anti-Chromobox Homolog 1 (CBX1) (N-Term) antibodyCBX1 适用: 人, 小鼠, 大鼠, 犬, Pig, Cow, 马, 兔, Saccharomyces cerevisiae, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromobox Homolog 1 (CBX1) (AA 176-185) antibodyCBX1 适用: 人, Hamster WB, IF, ChIP-seq 宿主: 兔 Polyclonal unconjugated
anti-Chromobox Homolog 1 (CBX1) antibodyCBX1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Chromobox Homolog 1 (CBX1) antibodyCBX1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ayoub, N., Jeyasekharan, A. D., Bernal, J. A., Venkitaraman, A. R. HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response. Nature 453: 682-686, 2008. 2. Bannister, A. J., Zegerman, P., Partridge, J. F., Miska, E. A., Thomas, J. O., Allshire, R. C., Kouzarides, T. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410: 120-124, 2001. 3. Cheutin, T., McNairn, A. J., Jenuwein, T., Gilbert, D. M., Singh, P. B., Misteli, T. Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science 299: 721-725, 2003. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- CBX1 (Chromobox Homolog 1 (CBX1))
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别名
- CBX1
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背景
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Synonyms: Transforming acidic coiled-coil-containing protein 1,Gastric cancer antigen Ga55,Taxin-1,TACC1,KIAA1103,
Tissue Specificity: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. .
Background: Chromobox protein homolog 1 is a protein that in humans is encoded by the CBX1 gene. This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.
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分子量
- 21 kDa
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基因ID
- 10951
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UniProt
- P83916
抗原
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