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XRN1 抗体 (AA 523-1198)

This anti-XRN1 antibody is a 兔 多克隆 antibody detecting XRN1 in WB, ICC, ELISA 和 IF. Suitable for 人 和 小鼠.
产品编号 ABIN7601966
发货至: 中国

Quick Overview for XRN1 抗体 (AA 523-1198) (ABIN7601966)

抗原

See all XRN1 抗体
XRN1 (5'-3' Exoribonuclease 1 (XRN1))

适用

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人, 小鼠

宿主

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克隆类型

  • 21
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多克隆

标记

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This XRN1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunocytochemistry (ICC), ELISA, Immunofluorescence (IF)
  • 抗原表位

    • 3
    • 2
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    • 1
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    AA 523-1198

    原理

    Anti-XRN1 Antibody Picoband®

    产品特性

    Anti-XRN1 Antibody Picoband® (ABIN7601966). Tested in WB, ICC/IF, ELISA applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human XRN1 recombinant protein (Position: K523-H1198). Human XRN1 shares 93.2% amino acid (aa) sequence identity with mouse XRN1.
  • 应用备注

    Western blot, 0.25-0.5 μg/mL, Human, Mouse
    Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
    ELISA, 0.1-0.5 μg/mL, -
    1. Bashkirov, V. I., Scherthan, H., Solinger, J. A., Buerstedde, J.-M., Heyer, W.-D. A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates. J. Cell Biol. 136: 761-773, 1997. 2. Gatfield, D., Izaurralde, E. Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature 429: 575-578, 2004. 3. Ingelfinger, D., Arndt-Jovin, D. J., Luhrmann, R., Achsel, T. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrn1 in distinct cytoplasmic foci. RNA 8: 1489-1501, 2002.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

    储存条件

    4 °C,-20 °C

    储存方法

    At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
  • 抗原

    XRN1 (5'-3' Exoribonuclease 1 (XRN1))

    别名

    XRN1

    背景

    5'-3' exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts ly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants.

    分子量

    200 kDa

    基因ID

    54464
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