PDE10A 抗体 (AA 515-779)
Quick Overview for PDE10A 抗体 (AA 515-779) (ABIN7601943)
抗原
See all PDE10A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 515-779
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原理
- Anti-PDE10A Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-PDE10A Antibody Picoband® (ABIN7601943). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PDE10A recombinant protein (Position: H515-D779).
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亚型
- IgG
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anti-phosphodiesterase 10A (PDE10A) antibody
PDE10A 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal 1B2 unconjugated
anti-phosphodiesterase 10A (PDE10A) (AA 508-779) antibodyPDE10A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 10A (PDE10A) (N-Term) antibodyPDE10A 适用: 人, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 10A (PDE10A) antibodyPDE10A 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 4A10 unconjugated
anti-phosphodiesterase 10A (PDE10A) (AA 23-200) antibodyPDE10A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 10A (PDE10A) (AA 242-333) antibodyPDE10A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-phosphodiesterase 10A (PDE10A) (N-Term) antibodyPDE10A 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-phosphodiesterase 10A (PDE10A) (AA 242-333) antibodyPDE10A 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4E1 unconjugated
anti-phosphodiesterase 10A (PDE10A) antibodyPDE10A 适用: 人 IF, FACS 宿主: 小鼠 Monoclonal 3G9 unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Diggle, C. P., Sukoff Rizzo, S. J., Popiolek, M., Hinttala, R., Schulke J.-P., Kurian, M. A., Carr, I. M., Markham, A. F., Bonthron, D. T., Watson, C., Sharif, S. M., Reinhart, V., and 30 others. Biallelic mutations in PDE10A lead to loss of striatal PDE10A and a hyperkinetic movement disorder with onset in infancy. Am. J. Hum. Genet. 98: 735-743, 2016. 2. Fujishige, K., Kotera, J., Michibata, H., Yuasa, K., Takebayashi, S., Okumura, K., Omori, K. Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J. Biol. Chem. 274: 18438-18445, 1999. 3. Fujishige, K., Kotera, J., Yuasa, K., Omori, K. The human phosphodiesterase PDE10A gene: genomic organization and evolutionarily relatedness with other PDEs containing GAF domains. Europ. J. Biochem. 267: 5943-5951, 2000. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- PDE10A (phosphodiesterase 10A (PDE10A))
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别名
- PDE10A
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背景
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Synonyms: Homeobox protein SIX3,Sine oculis homeobox homolog 3,SIX3,
Tissue Specificity: Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.
Background: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
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分子量
- 100 kDa
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基因ID
- 10846
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UniProt
- Q9Y233
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途径
- cAMP Metabolic Process
抗原
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