RNF168 抗体 (AA 5-571)
Quick Overview for RNF168 抗体 (AA 5-571) (ABIN7601889)
抗原
See all RNF168 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 5-571
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原理
- Anti-RNF168 Picoband® Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-R Picoband® Antibody (ABIN7601889). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human RNF168 recombinant protein (Position: K5-K571).
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亚型
- IgG
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anti-Ring Finger Protein 168 (RNF168) (AA 462-571) antibody
RNF168 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E1 unconjugated
anti-Ring Finger Protein 168 (RNF168) (C-Term) antibodyRNF168 适用: 人, 小鼠, 犬, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 1-571) antibodyRNF168 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 1-571) antibodyRNF168 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 401-450) antibodyRNF168 适用: 人, 小鼠, 犬, 大鼠, 豚鼠, 兔, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (C-Term) antibodyRNF168 适用: 人, 小鼠, 犬, 大鼠, 豚鼠, 兔, Cow, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 194-296) antibodyRNF168 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (AA 300-571) antibodyRNF168 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 168 (RNF168) (C-Term) antibodyRNF168 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Devgan, S. S., Sanal, O., Doil, C., Nakamura, K., Nahas, S. A., Pettijohn, K., Bartek, J., Lukas, C., Lukas, J., Gatti, R. A. Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia. Cell Death Diff. 18: 1500-1506, 2011. 2. Doil, C., Mailand, N., Bekker-Jensen, S., Menard, P., Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, J., Lukas, C. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 136: 435-446, 2009. 3. Nakada, S., Tai, I., Panier, S., Al-Hakim, A., Iemura, S., Juang, Y.-C., O'Donnell, L., Kumakubo, A., Munro, M., Sicheri, F., Gingras, A.-C., Natsume, T., Suda, T., Durocher, D. Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature 466: 941-946, 2010. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- RNF168 (Ring Finger Protein 168 (RNF168))
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别名
- RNF168
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背景
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Synonyms: E3 ubiquitin-protein ligase RNF168, hRNF168, RING finger protein 168, RING-type E3 ubiquitin transferase RNF168, RNF168
Tissue Specificity: Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
Background: Ring finger protein 168 is a protein that in humans is encoded by the RNF168 gene. It is mapped to 3q29. This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.
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分子量
- 65 kDa
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基因ID
- 165918
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途径
- Production of Molecular Mediator of Immune Response
抗原
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