ORAI1 抗体 (AA 49-301)
Our Local Distributor
北京 101111
Quick Overview for ORAI1 抗体 (AA 49-301) (ABIN7601852)
抗原
See all ORAI1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 49-301
-
原理
- Anti-Orai1 Antibody
-
特异性
- No cross reactivity with other proteins.
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-Orai1 Antibody. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human Orai1 recombinant protein (Position: A49-A301).
-
亚型
- IgG
-
-
anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) (2nd Extracellular Loop), (AA 200-212) antibody
KO Validated ORAI1 适用: 小鼠 WB, IHC, FACS, IF, LCI, IC 宿主: 兔 Polyclonal unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) (Internal Region) antibodyVerified ORAI1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) (C-Term) antibodyORAI1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) (AA 1-87) antibodyORAI1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) (AA 202-301) antibodyORAI1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) (2nd Extracellular Loop), (AA 203-214) antibodyKO Validated ORAI1 适用: 人 WB, IHC, FACS, IF, LCI, IC 宿主: 兔 Polyclonal unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) (Extracellular) antibodyORAI1 适用: 人 WB, FACS, IF, LCI, IC 宿主: 小鼠 Monoclonal 3F11-D10-B9 unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) antibodyORAI1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) (AA 145-173) antibodyORAI1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB25166 unconjugated
anti-ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) (AA 182-231) antibodyORAI1 适用: 人, Pig, 犬, 兔, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Western blot, 0.25-0.5 μg/mL Flow Cytometry (Fixed), 1-3 μg/1x106 cells ELISA, 0.1-0.5 μg/mL
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
-
-
- ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))
-
别名
- ORAI1
-
背景
-
Background: ORAI1 (ORAI calcium release-activated calcium modulator 1), also known as CRACM1, TMEM142A, Calcium release-activated calcium channel protein 1, Protein orai-1, Transmembrane protein 142A, FLJ14466, is a calcium selectiveion channelthat in humans is encoded by the ORAI1 gene. Orai1 channels play an important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans. The mammalian orai family has two additional homologs, orai2 and orai3. Orai proteins share no homology with any other ion channel family of any other known proteins. They have 4 transmembrane domains and form tetramers.Prakriya et al. showed that ORAI1 is a PM protein, and that CRAC channel function is sensitive to mutation of 2 conserved acidic residues in the transmembrane segments. Glu106-to-asp (E106D) and glu190-to-gln (E190Q) substitutions in transmembrane helices 1 and 3, respectively, diminished calcium ion influx, increased current carried by monovalent cations, and rendered the channel permeable to cesium ion.Prakriya et al. showed that ORAI1 is a PM protein, and that CRAC channel function is sensitive to mutation of 2 conserved acidic residues in the transmembrane segments.
Gene Full Name: ORAI calcium release-activated calcium modulator 1
-
分子量
- 39 kDa
-
基因ID
- 84876
-
UniProt
- Q96D31
-
途径
- TCR Signaling, BCR Signaling
抗原
-
