RAG2 抗体 (AA 46-503)
Quick Overview for RAG2 抗体 (AA 46-503) (ABIN7601803)
抗原
See all RAG2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 46-503
-
原理
- Anti-RAG2 Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins
-
产品特性
- Anti-RAG2 Antibody Picoband® (ABIN7601803). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human RAG2 recombinant protein (Position: F46-K503).
-
亚型
- IgG
-
-
anti-Recombination Activating Gene 2 (RAG2) (Center) antibody
RAG2 适用: 人, 大鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Recombination Activating Gene 2 (RAG2) (AA 1-527) antibodyRAG2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Recombination Activating Gene 2 (RAG2) (AA 428-527) antibodyRAG2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G8 unconjugated
anti-Recombination Activating Gene 2 (RAG2) (AA 258-527) antibodyRAG2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Recombination Activating Gene 2 (RAG2) (AA 498-527), (C-Term) antibodyRAG2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Recombination Activating Gene 2 (RAG2) (N-Term) antibodyRAG2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Recombination Activating Gene 2 (RAG2) (AA 1-527) antibodyRAG2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Recombination Activating Gene 2 (RAG2) (AA 350-527) antibodyRAG2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4D5 unconjugated
anti-Recombination Activating Gene 2 (RAG2) (AA 296-415) antibodyRAG2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Recombination Activating Gene 2 (RAG2) antibodyRAG2 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.25-0.5 μg/mL, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. "Entrez Gene: Recombination activating gene 2". 2. Callebaut, I., Mornon, J.-P. The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis. Cell. Molec. Life Sci. 54: 880-891, 1998. -
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
-
-
- RAG2 (Recombination Activating Gene 2 (RAG2))
-
别名
- RAG2
-
背景
-
Synonyms: Leptin receptor,LEP-R,HuB219,OB receptor,OB-R,CD295,LEPR,DB, OBR,
Tissue Specificity: Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
Background: Recombination activating gene 2, also known as RAG-2, is a protein that in humans is encoded by the RAG2 gene. This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
-
分子量
- 55 kDa
-
基因ID
- 5897
-
UniProt
- P55895
-
途径
- Chromatin Binding, Production of Molecular Mediator of Immune Response
抗原
-
