BIN1 抗体 (AA 45-593)
Quick Overview for BIN1 抗体 (AA 45-593) (ABIN7601780)
抗原
See all BIN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 45-593
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原理
- Anti-BIN1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-BIN1 Antibody Picoband® (ABIN7601780). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human BIN1 recombinant protein (Position: E45-P593).
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亚型
- IgG
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anti-Bridging Integrator 1 (BIN1) (AA 189-398) antibody
BIN1 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 3B6F10 unconjugated
anti-Bridging Integrator 1 (BIN1) antibodyBIN1 适用: 人, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bridging Integrator 1 (BIN1) (AA 230-409) antibodyBIN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bridging Integrator 1 (BIN1) antibodyBIN1 适用: 人 WB, IHC, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bridging Integrator 1 (BIN1) (AA 189-398) antibodyBIN1 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 3B6A4 unconjugated
anti-Bridging Integrator 1 (BIN1) (AA 414-593) antibodyBIN1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Bridging Integrator 1 (BIN1) (AA 1-482) antibodyBIN1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Bridging Integrator 1 (BIN1) (AA 355-454) antibodyBIN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C7 unconjugated
anti-Bridging Integrator 1 (BIN1) antibodyBIN1 适用: 小鼠 WB, IHC, ELISA, IP 宿主: 小鼠 Monoclonal 2F11 unconjugated
anti-Bridging Integrator 1 (BIN1) antibodyBIN1 适用: 人, 小鼠 WB, IHC, ELISA, IP, FACS 宿主: 小鼠 Monoclonal 99D unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Cabrera-Serrano, M., Mavillard, F., Biancalana, V., Rivas, E., Morar, B., Hernandez-Lain, A., Olive, M., Muelas, N., Khan, E., Carvajal, A., Quiroga, P., Diaz-Manera, J., and 10 others. A Roma founder BIN1 mutation causes a novel phenotype of centronuclear myopathy with rigid spine. Neurology 91: e339-e348, 2018. 2. Claeys, K. G., Maisonobe, T., Bohm, J., Laporte, J., Hezode, M., Romero, N. B., Brochier, G., Bitoun, M., Carlier, R. Y., Stojkovic, T. Phenotype of a patient with recessive centronuclear myopathy and a novel BIN1 mutation. Neurology 74: 519-521, 2010. 3. Di Paolo, G., Sankaranarayanan, S., Wenk, M. R., Daniell, L., Perucco, E., Caldarone, B. J., Flavell, R., Picciotto, M. R., Ryan, T. A., Cremona, O., De Camilli, P. Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Neuron 33: 789-804, 2002. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- BIN1 (Bridging Integrator 1 (BIN1))
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别名
- BIN1
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背景
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Synonyms: Rho-related GTP-binding protein RhoB, Rho cDNA clone 6, h6, RHOB, ARH6, ARHB
Tissue Specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
Background: Myc box-dependent-interacting protein 1, also known as Bridging Integrator-1 and Amphiphysin-2 is a protein that in humans is encoded by the BIN1 gene. This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
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分子量
- 65-80 kDa
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基因ID
- 274
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UniProt
- O00499
抗原
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