GRM2 抗体 (AA 439-710)
Quick Overview for GRM2 抗体 (AA 439-710) (ABIN7601733)
抗原
See all GRM2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 439-710
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原理
- Anti-Metabotropic glutamate receptor 2/GRM2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Metabotropic glutamate receptor 2/GRM2 Antibody (ABIN7601733). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Metabotropic glutamate receptor 2/GRM2 recombinant protein (Position: N439-A710).
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亚型
- IgG
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anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 414-558) antibody
GRM2 适用: 人 ELISA, WB, FACS 宿主: 小鼠 Monoclonal 6E4F6 unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 414-558) antibodyGRM2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4A10B9 unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (N-Term) antibodyGRM2 适用: 人, 兔, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (N-Term) antibodyGRM2 适用: 人, 大鼠, 小鼠, Cow, 犬, 兔, Hamster, Pig, Bat WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 109-121), (Extracellular) antibodyGRM2 适用: 大鼠 WB, IHC, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 93-221) antibodyGRM2 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (N-Term) antibodyGRM2 适用: 人, 大鼠, 犬, 兔, Hamster, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (Internal Region) antibodyVerified GRM2 适用: 人 ELISA, WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 801-872) antibodyGRM2 适用: 大鼠 ELISA, WB, IF (p), IHC (p), IF (cc), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Metabotropic 2 (GRM2) (AA 681-715) antibodyGRM2 适用: 人 WB 宿主: 兔 Polyclonal RB57773 unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Flor PJ, Lindauer K, Püttner I, Rüegg D, Lukic S, Knöpfel T, Kuhn R (April 1995). "Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2". The European Journal of Neuroscience. 7 (4): 622-9. 2. Kammermeier PJ, Davis MI, Ikeda SR (January 2003). "Specificity of metabotropic glutamate receptor 2 coupling to G proteins". Molecular Pharmacology. 63 (1): 183-91. 3. Jin LE, Wang M, Yang ST, Yang Y, Galvin VC, Lightbourne TC, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas CD, Arnsten AF (November 2017). "mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))
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别名
- GRM2
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背景
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Synonyms: Metabotropic glutamate receptor 2; mGluR2; GRM2; GPRC1B, MGLUR2
Tissue Specificity: Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.
Background: Metabotropic glutamate receptor 2 (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. It is mapped to 3p21.2. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
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分子量
- 100 kDa, >200 kDa
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基因ID
- 2912
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UniProt
- Q14416
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途径
- cAMP Metabolic Process, Dicarboxylic Acid Transport
抗原
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