DIS3 抗体 (AA 43-878)
Quick Overview for DIS3 抗体 (AA 43-878) (ABIN7601729)
抗原
See all DIS3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 43-878
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原理
- Anti-DIS3 Antibody Picoband®
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产品特性
- Anti-DIS3 Antibody Picoband® (ABIN7601729). Tested in WB, IHC, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human DIS3 recombinant protein (Position: H43-K878). Human DIS3 shares 92.8% amino acid (aa) sequence identity with mouse DIS3.
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anti-Exosome Complex Exonuclease RRP44 (DIS3) (AA 861-956) antibody
DIS3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2C7 unconjugated
anti-Exosome Complex Exonuclease RRP44 (DIS3) (AA 1-958) antibodyDIS3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Exosome Complex Exonuclease RRP44 (DIS3) (AA 861-956) antibodyDIS3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Exosome Complex Exonuclease RRP44 (DIS3) (AA 295-323) antibodyDIS3 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Exosome Complex Exonuclease RRP44 (DIS3) (AA 30-187) antibodyDIS3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Complex Exonuclease RRP44 (DIS3) (AA 290-339) antibodyDIS3 适用: 人, 小鼠, 大鼠, Cow, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Exosome Complex Exonuclease RRP44 (DIS3) (AA 1-280) antibodyDIS3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Complex Exonuclease RRP44 (DIS3) (AA 295-323) antibodyDIS3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB24091 unconjugated
anti-Exosome Complex Exonuclease RRP44 (DIS3) (AA 302-331), (Middle Region) antibodyDIS3 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry, 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Gross, M. B. Personal Communication. Baltimore, Md. 6/25/2014. 2. Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Hirosawa, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 63-70, 1999. 3. Rozenblum, E., Vahteristo, P., Sandberg, T., Bergthorsson, J. T., Syrjakoski, K., Weaver, D., Haraldsson, K., Johannsdottir, H. K., Vehmanen, P., Nigam, S., Golberger, N., Robbins, C., and 12 others. A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes. Hum. Genet. 110: 111-121, 2002. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))
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别名
- DIS3
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背景
- Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. The DIS3 gene encodes a catalytic subunit of the exosome complex, an essential RNA degradation machinery involved in multiple aspects of RNA metabolism, including RNA processing, quality control, and turnover. DIS3 functions as an exonuclease, playing a key role in degrading various RNA species, such as messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA). Its activity is crucial for maintaining cellular RNA homeostasis and gene expression regulation. Dysregulation of DIS3 expression or activity has been linked to various human diseases, including cancer and neurodegenerative disorders. Understanding the molecular mechanisms underlying DIS3 function is essential for elucidating its role in RNA metabolism and its potential implications for disease pathology and therapeutic targeting.
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分子量
- 109 kDa
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基因ID
- 22894
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UniProt
- Q9Y2L1
抗原
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