SMAD7 抗体 (AA 353-388)
Quick Overview for SMAD7 抗体 (AA 353-388) (ABIN7601444)
抗原
See all SMAD7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 353-388
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原理
- Anti-MADH7/SMAD7 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-MADH7/SMAD7 Antibody Picoband® (ABIN7601444). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MADH7/SMAD7 recombinant protein (Position: R353-Q388).
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亚型
- IgG
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anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (AA 1-100) antibody
SMAD7 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (AA 160-260) antibodySMAD7 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G10 unconjugated
anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (AA 160-260) antibodySMAD7 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3E9 unconjugated
anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (AA 195-224) antibodySMAD7 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (AA 302-400) antibodySMAD7 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3A11 unconjugated
anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (AA 160-260) antibodySMAD7 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4C11 unconjugated
anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (AA 36-247) antibodySMAD7 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (AA 195-224) antibodySMAD7 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB18598 unconjugated
anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (AA 160-260) antibodySMAD7 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 7 (SMAD7) (AA 49-317) antibodySMAD7 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Broderick, P., Carvajal-Carmona, L., Pittman, A. M., Webb, E., Howarth, K., Rowan, A., Lubbe, S., Spain, S., Sullivan, K., Fielding, S., Jaeger, E., Vijayakrishnan, J., and 20 others. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nature Genet. 39: 1315-1317, 2007. 2. Dong, C., Zhu, S., Wang, T., Yoon, W., Li, Z., Alvarez, R. J., ten Dijke, P., White, B., Wigley, F. M., Goldschmidt-Clermont, P. J. Deficient Smad7 expression: a putative molecular defect in scleroderma. Proc. Nat. Acad. Sci. 99: 3908-3913, 2002. Note: Retraction: Proc. Nat. Acad. Sci. 113: E2208, 2016. 3. Fukasawa, H., Yamamoto, T., Togawa, A., Ohashi, N., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M., Hishida, A. Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc. Nat. Acad. Sci. 101: 8687-8692, 2004. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))
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别名
- SMAD7
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背景
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Synonyms: Potassium voltage-gated channel subfamily H member 2, Eag homolog, Ether-a-go-go-related gene potassium channel 1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, Herg1, Voltage-gated potassium channel subunit Kv11.1, KCNH2, ERG, ERG1, HERG
Tissue Specificity: Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells.
Background: Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
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分子量
- 50 kDa
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基因ID
- 4092
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UniProt
- O15105
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途径
- Interferon-gamma Pathway, Cell-Cell Junction Organization
抗原
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