ITGA8 抗体 (AA 347-964)
Quick Overview for ITGA8 抗体 (AA 347-964) (ABIN7601411)
抗原
See all ITGA8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 347-964
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原理
- Anti-ITGA8 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-ITGA8 Antibody Picoband® (ABIN7601411). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human ITGA8 recombinant protein (Position: E347-D964).
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亚型
- IgG
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anti-Integrin alpha-8 (ITGA8) (AA 836-935) antibody
ITGA8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G7 unconjugated
anti-Integrin alpha-8 (ITGA8) (AA 907-1063) antibodyITGA8 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha-8 (ITGA8) (AA 1025-1053), (C-Term) antibodyITGA8 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB20555 unconjugated
anti-Integrin alpha-8 (ITGA8) (AA 114-131) antibodyITGA8 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha-8 (ITGA8) antibodyITGA8 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha-8 (ITGA8) (AA 836-935) antibodyITGA8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Integrin alpha-8 (ITGA8) antibodyITGA8 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha-8 (ITGA8) (C-Term) antibodyITGA8 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha-8 (ITGA8) (AA 251-300) antibodyITGA8 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Integrin alpha-8 (ITGA8) (AA 907-1000) antibodyITGA8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Humbert, C., Silbermann, F., Morar, B., Parisot, M., Zarhrate, M., Masson, C., Tores, F., Blanchet, P., Perez, M.-J., Petrov, Y., Khau Van Kien, P., Roume, J., and 9 others. Integrin alpha 8 recessive mutations are responsible for bilateral renal agenesis in humans. Am. J. Hum. Genet. 94: 288-294, 2014. Note: Erratum: Am. J. Hum. Genet. 94: 799 only, 2014. 2. Littlewood Evans, A. L., Muller, U. Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha-8/beta-1. Nature Genet. 24: 424-428, 2000. 3. Muller, U., Wang, D., Denda, S., Meneses, J. J., Pedersen, R. A., Reichardt, L. F. Integrin alpha-8/beta-1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell 88: 603-613, 1997. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- ITGA8 (Integrin alpha-8 (ITGA8))
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别名
- ITGA8
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背景
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Synonyms: Pancreatic secretory granule membrane major glycoprotein GP2, Pancreatic zymogen granule membrane protein GP-2, Gp2
Tissue Specificity: Expressed in all tissues tested including, liver, heart, adipose tissue, mammary gland, testes, ovary, brain, kidney and muscle. Highest levels in liver.
Background: Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene. Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms.
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分子量
- 180 kDa
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基因ID
- 8516
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UniProt
- P53708
抗原
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