MAG 抗体 (AA 34-605)
Quick Overview for MAG 抗体 (AA 34-605) (ABIN7601398)
抗原
See all MAG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 34-605
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原理
- Anti-MAG Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-MAG Antibody Picoband® (ABIN7601398). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MAG recombinant protein (Position: E34-R605).
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亚型
- IgG
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anti-Myelin Associated Glycoprotein (MAG) (AA 133-237) antibody
MAG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 25-516) antibodyMAG 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 119-208) antibodyMAG 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3C7 unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 439-466) antibodyMAG 适用: 人, 小鼠, 大鼠 WB, FACS 宿主: 兔 Polyclonal RB21439 unconjugated
anti-Myelin Associated Glycoprotein (MAG) antibodyMAG 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 114-132), (N-Term) antibodyMAG 适用: 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 501-582) antibodyMAG 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 551-626) antibodyMAG 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 119-209) antibodyMAG 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3C7 unconjugated
anti-Myelin Associated Glycoprotein (MAG) (C-Term) antibodyMAG 适用: 人, 大鼠 WB, IHC, IF, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.25 μg/mL, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Atwal, J. K., Pinkston-Gosse, J., Syken, J., Stawicki, S., Wu, J., Shatz, C., Tessier-Lavigne, M. PirB is a functional receptor for myelin inhibitors of axonal regeneration. Science 322: 967-970, 2008. 2. Barton, D. E., Arquint, M., Roder, J., Dunn, R., Francke, U. The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice. Genomics 1: 107-112, 1987. 3. Liu, B. P., Fournier, A., GrandPre, T., Strittmatter, S. M. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297: 1190-1193, 2002. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- MAG (Myelin Associated Glycoprotein (MAG))
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别名
- MAG
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背景
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Synonyms: Myelin-associated glycoprotein, Siglec-4a, MAG, GMA
Tissue Specificity: Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures. Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths. Detected in compact myelin (at protein level). Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system
Background: MAG (Myelin-associated glycoprotein),also known as SIGLEC4A, is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is though to be involved in the process of myelination. MAG is a sialic acid-binding SIGLEC protein and is a functional ligand for the NOGO receptor.The MAG gene is mapped on 19q13.12. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR. MAG binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner. Experiments blocking NgR from interacting with MAG prevented inhibition of neurite outgrowth by MAG. In cultured human embryonic kidney (HEK) cells expressing the NOGO receptor, p75 (NTR) was required for MAG-induced intracellular calcium elevation.
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分子量
- 100 kDa
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基因ID
- 4099
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UniProt
- P20916
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途径
- Neurotrophin Signaling Pathway
抗原
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