Claudin 18 抗体 (AA 31-261)
Quick Overview for Claudin 18 抗体 (AA 31-261) (ABIN7601257)
抗原
See all Claudin 18 (CLDN18) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 31-261
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原理
- Anti-Claudin18/CLDN18 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Claudin18/CLDN18 Antibody Picoband® (ABIN7601257). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Claudin18/CLDN18 recombinant protein (Position: S31-V261).
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亚型
- IgG
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anti-Claudin 18 (CLDN18) (AA 20-80) antibody
CLDN18 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Claudin 18 (CLDN18) (AA 196-261) antibodyCLDN18 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Claudin 18 (CLDN18) (C-Term) antibodyCLDN18 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Claudin 18 (CLDN18) (C-Term) antibodyCLDN18 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Claudin 18 (CLDN18) antibodyCLDN18 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal unconjugated
anti-Claudin 18 (CLDN18) (AA 196-261) antibodyCLDN18 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Claudin 18 (CLDN18) (C-Term) antibodyCLDN18 适用: 人, 大鼠, 犬, 马, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Claudin 18 (CLDN18) (AA 143-192) antibodyCLDN18 适用: 人, 小鼠, 大鼠, Cow, 兔, Pig, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Claudin 18 (CLDN18) (C-Term) antibodyCLDN18 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Claudin 18 (CLDN18) (AA 20-80) antibodyCLDN18 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Immunofluorescence, 5 μg/mL, Human, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Niimi, T., Nagashima, K., Ward, J. M., Minoo, P., Zimonjic, D. B., Popescu, N. C., Kimura, S. claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Molec. Cell. Biol. 21: 7380-7390, 2001. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- Claudin 18 (CLDN18)
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别名
- CLDN18
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背景
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Synonyms: Tudor domain-containing protein 3, TDRD3
Tissue Specificity: Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Background: Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
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分子量
- 30 kDa
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基因ID
- 51208
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UniProt
- P56856
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途径
- Cell-Cell Junction Organization, Hepatitis C
抗原
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