SMURF2 抗体 (AA 303-387)
Quick Overview for SMURF2 抗体 (AA 303-387) (ABIN7601239)
抗原
See all SMURF2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 303-387
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原理
- Anti-SMURF2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-SMURF2 Antibody Picoband® (ABIN7601239). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human SMURF 2/SMURF2 recombinant protein (Position: W303-Q387).
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亚型
- IgG
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anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (AA 601-700) antibody
SMURF2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) antibodySMURF2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (AA 702-731), (C-Term) antibodySMURF2 适用: 人, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB4107-4108 unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (AA 1-748) antibodySMURF2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (Internal Region) antibodySMURF2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) antibodySMURF2 适用: 人 WB 宿主: 小鼠 Monoclonal 1826CT865-51-28 unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (N-Term) antibodySMURF2 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) (C-Term) antibodySMURF2 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. "Entrez Gene: SMURF2 SMAD specific E3 ubiquitin protein ligase 2". 2. Blank, M., Tang, Y., Yamashita, M., Burkett, S. S., Cheng, S. Y., Zhang, Y. E. A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nature Med. 18: 227-234, 2012. 3. Lin X, Liang M, Feng XH (Nov 2000). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling". The Journal of Biological Chemistry 275(47): 36818-22. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
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别名
- SMURF2
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背景
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Synonyms: E3 ubiquitin-protein ligase SMURF2, hSMURF2, HECT-type E3 ubiquitin transferase SMURF2, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2, SMURF2
Tissue Specificity: Widely expressed.
Background: E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene. The SMURF2 gene is mapped to chromosome 17q22-q23 based on sequence similarity between the SMURF2 sequence and a genomic contig. SMURF2 is a HECT domain E3 ubiquitin ligase involved in degradation of SMADs, TGF-beta receptor (TGFBR), and other substrates. It also functions in regulation of neuronal and planar cell polarity, induction of senescence, and tumor suppression.
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分子量
- 86 kDa
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基因ID
- 64750
抗原
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