TMPRSS3 抗体 (AA 3-454)
Quick Overview for TMPRSS3 抗体 (AA 3-454) (ABIN7601198)
抗原
See all TMPRSS3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 3-454
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原理
- Anti-TMPRSS3 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-TMPRSS3 Antibody (ABIN7601198). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human TMPRSS3 recombinant protein (Position: E3-T454).
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亚型
- IgG
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anti-Transmembrane Protease, Serine 3 (TMPRSS3) (Internal Region) antibody
TMPRSS3 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, Serine 3 (TMPRSS3) (N-Term) antibodyTMPRSS3 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, Cow, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, Serine 3 (TMPRSS3) (C-Term) antibodyTMPRSS3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, Serine 3 (TMPRSS3) (AA 119-214) antibodyTMPRSS3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E1 unconjugated
anti-Transmembrane Protease, Serine 3 (TMPRSS3) (C-Term) antibodyTMPRSS3 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, Serine 3 (TMPRSS3) (C-Term) antibodyTMPRSS3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, Serine 3 (TMPRSS3) (AA 420-460) antibodyTMPRSS3 适用: 人, 小鼠 WB, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, Serine 3 (TMPRSS3) (AA 405-454) antibodyTMPRSS3 适用: 人, 小鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, Serine 3 (TMPRSS3) (N-Term) antibodyTMPRSS3 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, Cow, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Protease, Serine 3 (TMPRSS3) (Internal Region) antibodyVerified TMPRSS3 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ben-Yosef, T., Wattenhofer, M., Riazuddin, S., Ahmed, Z. M., Scott, H. S., Kudoh, J., Shibuya, K., Antonarakis, S. E., Bonne-Tamir, B., Radhakrishna, U., Naz, S., Ahmed, Z., Riazuddin, S., Pandya, A., Nance, W. E., Wilcox, E. R., Friedman, T. B., Morell, R. J. Novel mutations of TMPRSS3 in four DFNB8/B10 families segregating congenital autosomal recessive deafness. (Letter) J. Med. Genet. 38: 396-400, 2001. 2. Fasquelle, L., Scott, H. S., Lenoir, M., Wang, J., Rebillard, G., Goboyard, S., Venteo, S., Francois, F., Mausset-Bonnefont, A.-L., Antonarakis, S. E., Neidhart, E., Chabbert, C., Puel, J.-L., Guipponi, M., Delprat, B. Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing. J. Biol. Chem. 286: 17383-17397, 2011. 3. Guipponi, M., Vuagniaux, G., Wattenhofer, M., Shibuya, K., Vazquez, M., Dougherty, L., Scamuffa, N., Guida, E., Okui, M., Rossier, C., Hancock, M., Buchet, K., Reymond, A., Hummler, E., Marzella, P. L., Kudoh, J., Shimizu, N., Scott, H. S., Antonarakis, S. E., Rossier, B. C. The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro. Hum. Molec. Genet. 11: 2829-2836, 2002. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- TMPRSS3 (Transmembrane Protease, Serine 3 (TMPRSS3))
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别名
- TMPRSS3
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背景
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Synonyms: Eukaryotic peptide chain release factor subunit 1, Eukaryotic release factor 1, Erf1, Protein Cl1, TB3-1, ETF1, ERF1, RF1, SUP45L1
Tissue Specificity: Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.
Background: Transmembrane protease, serine 3 is an enzyme that in humans is encoded by the TMPRSS3 gene. This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.
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分子量
- 48 kDa
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基因ID
- 64699
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UniProt
- P57727
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途径
- Sensory Perception of Sound
抗原
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