CLCN3 抗体 (AA 293-752)
Quick Overview for CLCN3 抗体 (AA 293-752) (ABIN7601156)
抗原
See all CLCN3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 293-752
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原理
- Anti-CLCN3 Antibody Picoband®
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产品特性
- Anti-CLCN3 Antibody Picoband® (ABIN7601156). Tested in WB, IF, IHC, ICC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human CLCN3 recombinant protein (Position: G293-R752). Human CLCN3 shares 99.6% amino acid (aa) sequence identity with mouse CLCN3.
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anti-Chloride Channel 3 (CLCN3) (C-Term) antibody
CLCN3 适用: 大鼠, 人, 小鼠, 豚鼠, 兔, 犬, 斑马鱼, 马, Cow, 绵羊 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel 3 (CLCN3) (N-Term) antibodyCLCN3 适用: 大鼠, 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel 3 (CLCN3) (AA 98-115) antibodyCLCN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S258-5 unconjugated
anti-Chloride Channel 3 (CLCN3) (AA 98-115) antibody (HRP)CLCN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S258-5 HRP
anti-Chloride Channel 3 (CLCN3) (AA 98-115) antibody (FITC)CLCN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S258-5 FITC
anti-Chloride Channel 3 (CLCN3) (AA 98-115) antibody (Biotin)CLCN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S258-5 Biotin
anti-Chloride Channel 3 (CLCN3) (AA 98-115) antibody (PE)CLCN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S258-5 PE
anti-Chloride Channel 3 (CLCN3) (AA 98-115) antibody (APC)CLCN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S258-5 APC
anti-Chloride Channel 3 (CLCN3) (AA 98-115) antibody (PerCP)CLCN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S258-5 PerCP
anti-Chloride Channel 3 (CLCN3) (AA 98-115) antibody (Atto 594)CLCN3 适用: 大鼠 WB, IHC, ICC, IF 宿主: 小鼠 Monoclonal S258-5 Atto 594
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry, 2-5 μg/mL, Human, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Borsani, G., Rugarli, E. I., Taglialatela, M., Wong, C., Ballabio, A. Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein. Genomics 27: 131-141, 1995. 2. Duncan, A. R., Polovitskaya, M. M., Gaitan-Penas, H., Bertelli, S., VanNoy, G. E., Grant, P. E., O'Donnell-Luria, A., Valivullah, Z., Lovgren, A. K., England, E. M., Agolini, E., Madden, J. A., and 28 others. Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders. Am. J. Hum. Genet. 108: 1450-1465, 2021. 3. Mills, K. A., Mathews, K. D., Scherpbier-Heddema, T., Buetow, K. H., Baldini, A., Ballabio, A., Borsani, G. Genetic and physical mapping of a voltage-dependent chloride channel gene to human 4q32 and to mouse 8. Genomics 36: 374-376, 1996. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- CLCN3 (Chloride Channel 3 (CLCN3))
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别名
- CLCN3
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背景
- H+/Cl? exchange transporter 3 is a protein that in humans is encoded by the CLCN3 gene. This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
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分子量
- 170 kDa
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基因ID
- 1182
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UniProt
- P51790
抗原
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