GRB7 抗体 (AA 29-256)
Quick Overview for GRB7 抗体 (AA 29-256) (ABIN7601118)
抗原
See all GRB7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 29-256
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原理
- Anti-GRB7 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-GRB7 Antibody Picoband® (ABIN7601118). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human GRB7 recombinant protein (Position: R29-S256).
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亚型
- IgG
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anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 298-489) antibody
GRB7 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 1-532) antibodyGRB7 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 1-532) antibodyGRB7 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 66-327) antibodyGRB7 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 37-136) antibodyGRB7 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3C12 unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 233-532) antibodyGRB7 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) antibodyGRB7 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (AA 124-141), (Middle Region) antibodyGRB7 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (N-Term) antibodyGRB7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 7 (GRB7) (N-Term) antibodyVerified GRB7 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Tanaka, S., Mori, M., Akiyoshi, T., Tanaka, Y., Mafune, K., Wands, J. R., Sugimachi, K.A novel variant of human Grb7 is associated with invasive esophageal carcinoma.J. Clin. Invest. 102: 821-827, 1998. 2. Vayssiere, B., Zalcman, G., Mahe, Y., Mirey, G., Ligensa, T., Weidner, K. M., Chardin, P., Camonis, J.Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family.FEBS Lett. 467: 91-96, 2000. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))
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别名
- GRB7
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背景
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Synonyms: Natural killer cell receptor 2B4, Cd244, LOC685808
Tissue Specificity: Expressed in natural killer (NK) cells, T cells and dendritic cells.
Background: GRB7, growth factor receptor-bound protein 7, is a protein which in humans is encoded by the GRB7 gene. The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date. GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular link to the Ras proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias HER2/neu) proto-oncogene. These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7 though to be involved in migration, is well known to be over-expressed in testicular germ cell tumors, esophageal cancers, and gastric cancers.
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分子量
- 60 kDa
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基因ID
- 2886
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UniProt
- Q14451
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途径
- EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization
抗原
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