FTO 抗体 (AA 279-505)
Quick Overview for FTO 抗体 (AA 279-505) (ABIN7601059)
抗原
See all FTO 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 279-505
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原理
- Anti-FTO Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-FTO Antibody Picoband® (ABIN7601059). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human FTO recombinant protein (Position: D279-P505).
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亚型
- IgG
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anti-Fat Mass and Obesity-Associated (FTO) antibody
FTO 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Monoclonal 4G9 unconjugated Recombinant Antibody
anti-Fat Mass and Obesity-Associated (FTO) antibodyFTO 适用: 小鼠 WB, ELISA, IHC, IP 宿主: 小鼠 Monoclonal FT62-6 unconjugated
anti-Fat Mass and Obesity-Associated (FTO) antibodyFTO 适用: 人 WB, ELISA, IHC, IP 宿主: 小鼠 Monoclonal AG103 unconjugated
anti-Fat Mass and Obesity-Associated (FTO) antibodyFTO 适用: 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fat Mass and Obesity-Associated (FTO) antibodyFTO 适用: 人, 小鼠, 大鼠, 犬, Cow, 绵羊, 马, 灵长类 WB, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 5-2H10 unconjugated
anti-Fat Mass and Obesity-Associated (FTO) antibodyFTO 适用: 人, 小鼠, 大鼠 WB, ELISA, IP 宿主: 小鼠 Monoclonal FT86-4 unconjugated
anti-Fat Mass and Obesity-Associated (FTO) (AA 416-505) antibodyFTO 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Fat Mass and Obesity-Associated (FTO) (N-Term) antibodyFTO 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 5-2H10 unconjugated
anti-Fat Mass and Obesity-Associated (FTO) (AA 1-30), (N-Term) antibodyFTO 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB21572 unconjugated
anti-Fat Mass and Obesity-Associated (FTO) antibodyFTO 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Boissel, S., Reish, O., Proulx, K., Kawagoe-Takaki, H., Sedgwick, B., Yeo, G. S. H., Meyre, D., Golzio, C., Molinari, F., Kadhom, N., Etchevers, H. C., Saudek, V., Farooqi, I. S., Froguel, P., Lindahl, T., O'Rahilly, S., Munnich, A., Colleaux, L. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am. J. Hum. Genet. 85: 106-111, 2009. 2. Church, C., Moir, L., McMurray, F., Girard, C., Banks, G. T., Teboul, L., Wells, S., Bruning, J. C., Nolan, P. M., Ashcroft, F. M., Cox, R. D. Overexpression of Fto leads to increased food intake and results in obesity. Nature Genet. 42: 1086-1092, 2010. 3. Claussnitzer, M., Dankel, S. N., Kim, K.-H., Quon, G., Meuleman, W., Haugen, C., Glunk, V., Sousa, I. S., Beaudry, J. L., Puviindran, V., Abdennur, N. A., Liu, J., Svensson, P.-A., Hsu, Y.-H., Drucker, D. J., Mellgren, G., Hui, C.-C., Hauner, H., Kellis, M. FTO obesity variant circuitry and adipocyte browning in humans. New Eng. J. Med. 373: 895-907, 2015. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- FTO (Fat Mass and Obesity-Associated (FTO))
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别名
- FTO
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背景
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Synonyms: GTP-binding nuclear protein Ran,Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein,RAN,ARA24,OK/SW-cl.81,
Tissue Specificity: Expressed in a variety of tissues. .
Background: Fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase FTO is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
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分子量
- 58 kDa
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基因ID
- 79068
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UniProt
- Q9C0B1
抗原
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